DEVELOPMENTAL FUNDS. During the current grant period, MSKCC opened the first phase of the Zuckerman Research Center. This allowed additional space for MSKCC to expand its laboratory-based cancer research efforts. An effort to attract leading laboratory-based junior investigators was begun in 2006. The strategic planning for these recruitments was undertaken by the Senior Leadership and executed by search committees led by the Program Leaders with participation from the membership. To date, 17 junior investigators have been recruited and established independent laboratories in part supported by the CCSG funds. Over the last 6 years, a total of $4.7M in developmental funds were awarded to assist in establishing their laboratories. These funds have been instrumental in the success of these junior investigators at establishing successful independent laboratories. As a group they have received $38.1M in peer-reviewed funding (total award) and produced over 80 publications from their laboratories. All 8 of the laboratory-based research programs participated in and benefited from this influx of emerging talent. Many of the new investigators brought with them expertise in new areas or techniques of relevance to the evolving scope of cancer research. Funds are now being requested to support the mission of the Cancer Center in two categories critical to the advancement of its goals: 1) Additional faculty recruitment in disciplines related to the strategic vision of the Center and 2) Pilot project grants to stimulate cross-disciplinary collaboration between investigators in the Survivorship, Outcomes and Risk (SOAR) program and members of other Cancer Center programs. Both categories represent opportunities for the Center to strengthen and diversify its research portfolio. Funds requested to support faculty recruitment in strategic areas will enable the Center to attract top talent by providing a start-up/transition package that will enable new recruits to have the resources to immediately develop and grow their research programs. Funds requested to support cross-disciplinary pilot projects between SOAR and other Cancer Center program members will provide an opportunity for the development and initiation of research projects that build upon the expertise of the Center's population scientists, as well as exploit the knowledge of the Center's basic and clinical research community in order to facilitate the discovery of new knowledge.

Public Health Relevance

The recruitment of faculty in strategic areas, as well as the initiation of pilot projects bridging population sciences with other areas of investigation are critical elements to facilitating the discovery of new cancer-related knowledge.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA008748-48
Application #
8933481
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
2014-01-01
Project End
2018-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
48
Fiscal Year
2014
Total Cost
$1,421,601
Indirect Cost
$621,601
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Orlow, I; Satagopan, J M; Berwick, M et al. (2015) Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC). Br J Dermatol 172:1081-9
Carey, Bryce W; Finley, Lydia W S; Cross, Justin R et al. (2015) Intracellular ?-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518:413-6
Mosher, C E; Given, B A; Ostroff, J S (2015) Barriers to mental health service use among distressed family caregivers of lung cancer patients. Eur J Cancer Care (Engl) 24:50-9
Navi, Babak B; Reiner, Anne S; Kamel, Hooman et al. (2015) Association between incident cancer and subsequent stroke. Ann Neurol 77:291-300
Xu, Zhe; Wu, Chaochao; Xie, Fang et al. (2015) Comprehensive quantitative analysis of ovarian and breast cancer tumor peptidomes. J Proteome Res 14:422-33
Xu, Hong; Cheng, Ming; Guo, Hongfen et al. (2015) Retargeting T cells to GD2 pentasaccharide on human tumors using Bispecific humanized antibody. Cancer Immunol Res 3:266-77
Gondo, Tatsuo; Poon, Bing Ying; Matsumoto, Kazuhiro et al. (2015) Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy confirmed Gleason score 3 + 4 prostate cancer. BJU Int 115:81-6
Ripley, R Taylor; McMillan, Robert R; Sima, Camelia S et al. (2014) Second primary lung cancers: smokers versus nonsmokers after resection of stage I lung adenocarcinoma. Ann Thorac Surg 98:968-74
Ye, Jiangbin; Fan, Jing; Venneti, Sriram et al. (2014) Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov 4:1406-17
Lu, Zhigang; Xu, Jin; Xu, Mingming et al. (2014) Morphine regulates expression of *-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the *-opioid receptor (OPRM1) gene via miR-103/miR-107. Mol Pharmacol 85:368-80

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