The Pathology Core provides a comprehensive resource for human tissue-based research that takes advantage of the unique tissue resources available at the Center. Acquisition and banking of human biologic specimens to be used in studying the causes, detection, prevention and treatment of cancer has become an indelible source for supporting basic and translational cancer research in various laboratories throughout the Center. The reliability of molecular data derived from new technology platforms ultimately requires an adequate supply of optimally procured, high quality tissue specimens. The Pathology Core at MSKCC has capacity to meet this challenge and is designed as an efficient and cost-effective means to facilitate tissue use, to assist investigators with expertise in oncologic pathology and to conduct tissue-associated experimentation. The Pathology Core also serves as a national resource, as evidenced by the over 1,000 samples from multiple tumor types that have been provided to the NCI-funded Cancer Genome Atlas initiative. The Histology service within the Core facilitates selection of appropriate specimens for tissue analyses and provides basic service of cutting, dissecting and staining of fresh frozen and formalin fixed, paraffin embedded tissue. It includes construction of tissue microarray blocks and laser capture microdissection for isolation of pure cell populations and tumor cell enrichment. The Core Immunohistochemistry service provides automated and manual staining of optimized monoclonal and polyclonal antibodies to be used in clinico-pathologic correlative studies. This service also develops protocols for new antibody characterizations by using cell lines, xenograft tissue and variety of antigen retrieval and detection systems. The services and collaborative work provided by the Pathology Core has supported the research of 116 investigators in the past year. During the past grant period the work of the Core has contributed to 1320 publications of researchers from 7 research programs.
The Pathology Core provides a comprehensive resource for human tissue-based research that takes advantage of the unique tissue resource available at the Center. The services that the Pathology Core provide are fundamental to the translational mission of the Center.
|Steuer, Conor E; Behera, Madhusmita; Berry, Lynne et al. (2016) Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium. Cancer 122:766-72|
|Dominguez-Rosado, Ismael; Moutinho Jr, Vitor; DeMatteo, Ronald P et al. (2016) Outcomes of the Memorial Sloan Kettering Cancer Center International General Surgical Oncology Fellowship. J Am Coll Surg 222:961-6|
|Iasonos, Alexia; O'Quigley, John (2016) Integrating the escalation and dose expansion studies into a unified Phase I clinical trial. Contemp Clin Trials 50:124-34|
|Ulaner, Gary A; Hyman, David M; Ross, Dara S et al. (2016) Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer Using 89Zr-Trastuzumab PET/CT. J Nucl Med 57:1523-1528|
|Brown, Anna M; Nagala, Sidhartha; McLean, Mary A et al. (2016) Multi-institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion-weighted MRI. Magn Reson Med 75:1708-16|
|Akkari, Leila; Gocheva, Vasilena; Quick, Marsha L et al. (2016) Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev 30:220-32|
|Theilen, Till M; Chou, Alexander J; Klimstra, David S et al. (2016) Esophageal Adenocarcinoma and Squamous Cell Carcinoma in Children and Adolescents: Report of 3 Cases and Comprehensive Literature Review. J Pediatr Surg Case Rep 5:23-29|
|Robinson, June K; Halpern, Allan C (2016) Cost-effective Melanoma Screening. JAMA Dermatol 152:19-21|
|Calzavara-Pinton, Pier Giacomo; Rossi, Maria Teresa; Zanca, Arianna et al. (2016) Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study. Photodermatol Photoimmunol Photomed 32:22-7|
|Ripley, R Taylor; Suzuki, Kei; Tan, Kay See et al. (2016) Postinduction positron emission tomography assessment of N2 nodes is not associated with ypN2 disease or overall survival in stage IIIA non-small cell lung cancer. J Thorac Cardiovasc Surg 151:969-77, 979.e1-3|
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