The Biostatistics Core Facility provides long-term collaborative support to established programs of research at the Center, and short-term consulting services. The work of the Facility enhances the scientific objectives of the Center's research programs by providing expertise on study design and statistical analysis. The field of biostatistics is devoted to developing an understanding of the appropriate ways to derive scientific inferences from quantitative data, and to developing methods for achieving this aim. The staff is highly trained in this field and were all recruited after extensive national searches. The Facility consists of 19 doctoral-level faculty biostatisticians, assisted by 14 masters-level biostatisticians, and a team of programming staff and administrative staff. The doctoral-level biostatisticians in the Facility have broad, collective experience in all of the specialized areas of statistical techniques that are pertinent to contemporary cancer research, including clinical trials methodology, actuarial techniques, epidemiologic methods, analysis of genomics data, statistical genetics, methods for diagnostic medicine, evidence-based medicine and psychometric methods. Cost recovery is achieved primarily through involvement of the Facility members and staff as funded co-investigators on NIH grants. By providing a valid framework for the design, conduct and analysis of scientific studies, the Core contributes to scientific quality and promotes interdisciplinary research. The broad range of services and collaborative work provided by the Biostatistics Core has supported the research of 340 investigators in the past year. During the past grant period the work of the Core has contributed to 1,932 publications of researchers from 9 research programs. For example, the Biostatistics Core Facility played a key role in the recently-published TCGA lung squamous cell carcinoma study that comprehensively characterized the genomic, epigenomic, and transcriptomic landscape of 178 lung SCC samples. This study used an integrative clustering method developed by the facility (iCluster+) to identify sub-types of lung cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA008748-48
Application #
8933554
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
2014-01-01
Project End
2018-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
48
Fiscal Year
2014
Total Cost
$944,198
Indirect Cost
$412,854
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Steuer, Conor E; Behera, Madhusmita; Berry, Lynne et al. (2016) Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium. Cancer 122:766-72
Dominguez-Rosado, Ismael; Moutinho Jr, Vitor; DeMatteo, Ronald P et al. (2016) Outcomes of the Memorial Sloan Kettering Cancer Center International General Surgical Oncology Fellowship. J Am Coll Surg 222:961-6
Iasonos, Alexia; O'Quigley, John (2016) Integrating the escalation and dose expansion studies into a unified Phase I clinical trial. Contemp Clin Trials 50:124-34
Ulaner, Gary A; Hyman, David M; Ross, Dara S et al. (2016) Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer Using 89Zr-Trastuzumab PET/CT. J Nucl Med 57:1523-1528
Brown, Anna M; Nagala, Sidhartha; McLean, Mary A et al. (2016) Multi-institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion-weighted MRI. Magn Reson Med 75:1708-16
Akkari, Leila; Gocheva, Vasilena; Quick, Marsha L et al. (2016) Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev 30:220-32
Theilen, Till M; Chou, Alexander J; Klimstra, David S et al. (2016) Esophageal Adenocarcinoma and Squamous Cell Carcinoma in Children and Adolescents: Report of 3 Cases and Comprehensive Literature Review. J Pediatr Surg Case Rep 5:23-29
Robinson, June K; Halpern, Allan C (2016) Cost-effective Melanoma Screening. JAMA Dermatol 152:19-21
Calzavara-Pinton, Pier Giacomo; Rossi, Maria Teresa; Zanca, Arianna et al. (2016) Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study. Photodermatol Photoimmunol Photomed 32:22-7
Ripley, R Taylor; Suzuki, Kei; Tan, Kay See et al. (2016) Postinduction positron emission tomography assessment of N2 nodes is not associated with ypN2 disease or overall survival in stage IIIA non-small cell lung cancer. J Thorac Cardiovasc Surg 151:969-77, 979.e1-3

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