: Developmental Funds have continued to play a key role in the global reorganization of the Cancer Center that was initiated during the last CCSG budget period. Supported by a thorough, transparent and inclusive strategic planning process, the Cancer Center has undergone major changes in its administrative infrastructure, refinement of scientific and educational objectives, expansion of programmatic themes and global realignment of Shared Resources. A pivotal aspect of this reorganization was a focused and thematic faculty recruitment effort that led to the hiring of nine new Cancer Center members at all academic ranks and appointed across the three scientific Programs during the last budget period. Judiciously deployed as part of a flexible, inclusive and goal-oriented decision-making process, CCSG Developmental Funds have been instrumental to enable the long-range directives ofthe 2012 Cancer Center Strategic Plan, contributing to new faculty recruitment, facilitating inter-programmatic and collaborative pilot projects, supporting the launch of a new developmental Translational Research Management core, and expanding the collection of clinically annotated primary tumor samples for molecular validation studies, prognostic biomarker assessment and identification of new cancer targets. In this context, CCSG Developmental Funds have tangibly contributed to the sharp upward trajectory of the Cancer Center of the last budget period, reflected in significantly increased cancer focus, growth in NCI and cancer-related funding, expansion of inter- and intraprogrammatic collaborative publications, and launch of a portfolio of scientific initiatives along the continuum of basic, translational and patient-oriented cancer research. Building on these validated principles, CCSG Developmental Funds will continue to support the upward trajectory of the Cancer Center over the next budget period, supporting new faculty recruitment and expanding the Center-wide tools that have been put in place to enable translational and patient-oriented cancer research across all three scientific Programs.

Public Health Relevance

CCSG Developmental Funds have provided a critical asset to enable the transformative changes introduced in the Cancer Center during the last CCSG budget period, especially in the areas of new faculty recruitment and translational cancer research. A detailed plan has been formulated to build on these accomplishments and continue on the trajectory of growth of the cancer research agenda ahead of the upcoming faculty and facility expansion

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA010815-49
Application #
9438878
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
49
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
075524595
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wu, Shuai; Fatkhutdinov, Nail; Fukumoto, Takeshi et al. (2018) SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells. Nat Commun 9:4116
Ecker, Brett L; Kaur, Amanpreet; Douglass, Stephen M et al. (2018) Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. Cancer Discov :
Abdel-Mohsen, Mohamed; Kuri-Cervantes, Leticia; Grau-Exposito, Judith et al. (2018) CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells. Sci Transl Med 10:
Fukumoto, Takeshi; Magno, Elizabeth; Zhang, Rugang (2018) SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications. Mol Cancer Res 16:1819-1825
Cañadas, Israel; Thummalapalli, Rohit; Kim, Jong Wook et al. (2018) Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Nat Med 24:1143-1150
Basu, Subhasree; Gnanapradeepan, Keerthana; Barnoud, Thibaut et al. (2018) Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1?. Genes Dev 32:230-243
Perales-Puchalt, Alfredo; Perez-Sanz, Jairo; Payne, Kyle K et al. (2018) Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol 103:799-805
Colón, Krystal; Speicher, David W; Smith, Peter et al. (2018) S100a14 is Increased in Activated Nk Cells and Plasma of HIV-Exposed Seronegative People Who Inject Drugs and Promotes Monocyte-Nk crosstalk. J Acquir Immune Defic Syndr :
Schug, Zachary T (2018) Formaldehyde Detoxification Creates a New Wheel for the Folate-Driven One-Carbon ""Bi""-cycle. Biochemistry 57:889-890
Karakashev, Sergey; Zhu, Hengrui; Wu, Shuai et al. (2018) CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity. Nat Commun 9:631

Showing the most recent 10 out of 741 publications