DEVELOPMENTAL FUNDS In the current funding period, Developmental funds have been used for three purposes: 1) pilot funds, 2) recruitment of investigators, and 3) shared resource development. We propose in the next funding cycle to continue funding in these three categories and to add a fourth category for bridge funding. The increased budget for developmental funds when compared to the last grant is related to our proposal to develop three new shared resources: a behavioral measurement core for Cancer Control investigators, a animal and human tumor imaging core to support this major focus of the Clinical Research program, and a crystallography core to support the basic science Programs. These are described in detail later in this section. We will first discuss the use of developmental funds in the current grant period (section A), and then describe the uses of funds proposed in this application (section B). At the end of this section, we have appended a list of individual pilot grants, with an indication of whether they obtained peer-reviewed funds as a consequence of our pilot funding. We have appended a selected list of publications that have resulted from use of pilot funds.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA012197-36
Application #
8213156
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
36
Fiscal Year
2011
Total Cost
$479,189
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Chouliaras, Konstantinos; Levine, Edward A; Fino, Nora et al. (2017) Prognostic Factors and Significance of Gastrointestinal Leak After Cytoreductive Surgery (CRS) with Heated Intraperitoneal Chemotherapy (HIPEC). Ann Surg Oncol 24:890-897
Wang, Lulu; Habib, Amyn A; Mintz, Akiva et al. (2017) Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential. Mol Imaging 16:1536012117708722
Keim-Malpass, Jessica; Mihalko, Shannon L; Russell, Greg et al. (2017) Problems Experienced by Ovarian Cancer Survivors During Treatment. J Obstet Gynecol Neonatal Nurs 46:544-554
Ivey, Jill W; Latouche, Eduardo L; Richards, Megan L et al. (2017) Enhancing Irreversible Electroporation by Manipulating Cellular Biophysics with a Molecular Adjuvant. Biophys J 113:472-480
Rohlfing, Matthew L; Mays, Ashley C; Isom, Scott et al. (2017) Insurance status as a predictor of mortality in patients undergoing head and neck cancer surgery. Laryngoscope 127:2784-2789
Soto-Pantoja, David R; Wilson, Adam S; Clear, Kenysha Yj et al. (2017) Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness. Oncotarget 8:80545-80559
Park, Sun H; Eber, Matthew R; Tsuzuki, Shunsuke et al. (2017) Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice. Sci Rep 7:17428
Andrews, Rachel N; Metheny-Barlow, Linda J; Peiffer, Ann M et al. (2017) Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates. Radiat Res 187:599-611
Carpenter, Richard L; Sirkisoon, Sherona; Zhu, Dongqin et al. (2017) Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget 8:73947-73963
Wajih, Nadeem; Basu, Swati; Jailwala, Anuj et al. (2017) Potential therapeutic action of nitrite in sickle cell disease. Redox Biol 12:1026-1039

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