The major goal of the Clinical Research Program (CRP) of the Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) is to serve as a hypothesis-driven incubator and catalyst for the clinical translation of novel therapeutic, diagnostic, and supportive care strategies. The goal of the CRP will be achieved through the following Specific Aims: (1) Translate advances in the understanding of cancer from the WFBCCC's basic sciences and population science Programs into novel therapeutic strategies with correlative biomarkers of response; (2) Promote the development and conduct of innovative clinical trials for rare or difficult to treat cancers and sites of metastasis; and (3) Enhance understanding in cancer-related symptom science, including leveraging the Wake Forest National Cancer Institute Community Oncology Program Research Base (WF NCORP RB; PI: Glenn Lesser, M.D.). CRP research is comprised of two themes within these aims: experimental therapeutics and addressing health disparities, with particular focus on cancers of high incidence in the WFBCCC catchment area. CRP is led by William Blackstock, M.D., with Dr. Lesser appointed as Program Co-Leader in August of 2015. The Program has 43 members from 17 different departments. Program members have $4.5M in peer-reviewed extramural funding (excluding training grants) of which 58.7% is from the NCI. Among the members' 513 publications, 23% were intra-programmatic, 14% were inter-programmatic, and 63% were inter-institutional during the 11/01/10 ? 10/31/15 reporting period. The CRP has benefited from the ability to use the WF NCORP RB network as a platform for community-based clinical trials; in turn, the WF NCORP RB can translate the expertise of the CRP's clinician-scientists, strengthening each of these NCI- supported entities. Twelve Disease-Oriented Teams (DOTs) have been formalized within the WFBCCC research infrastructure to further enhance translation of WFBCCC science. Each DOT has a specific focus: brain, breast, geriatrics, gastrointestinal, genitourinary, gynecologic, head and neck, hematologic, lung, melanoma, pediatrics, and sarcoma. DOTs are comprised of basic scientists, population scientists, and clinicians, and serve as vehicles for robust interprogrammatic interactions leading to more innovative and comprehensive research portfolios. During the Data Table 3 reporting period of 07/01/14-06/30/15, 268 trials were open and 2,875 patients were accrued. Sixty-three percent of the trials were treatment trials, 15% were non-treatment interventions, and 21% were non-interventional studies. Twelve percent of treatment trials were investigator-initiated.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA012197-43S2
Application #
9757056
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Belin, Precilla L
Project Start
Project End
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
43
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Rimkus, Tadas K; Carpenter, Richard L; Sirkisoon, Sherona et al. (2018) Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44. Cancer Res 78:2589-2600
Bonin, Keith; Smelser, Amanda; Moreno, Naike Salvador et al. (2018) Structured illumination to spatially map chromatin motions. J Biomed Opt 23:1-8
Rogers, LeAnn C; Davis, Ryan R; Said, Naveen et al. (2018) Blocking LPA-dependent signaling increases ovarian cancer cell death in response to chemotherapy. Redox Biol 15:380-386
Maggiore, Ronald J; Callahan, Kathryn E; Tooze, Janet A et al. (2018) Geriatrics fellowship training and the role of geriatricians in older adult cancer care: A survey of geriatrics fellowship directors. Gerontol Geriatr Educ 39:170-182
Melvin, Ryan L; Xiao, Jiajie; Godwin, Ryan C et al. (2018) Visualizing correlated motion with HDBSCAN clustering. Protein Sci 27:62-75
Faig, Jennifer; Haughton, Michael; Taylor, Richard C et al. (2018) Retrospective Analysis of Cisplatin Nephrotoxicity in Patients With Head and Neck Cancer Receiving Outpatient Treatment With Concurrent High-dose Cisplatin and Radiotherapy. Am J Clin Oncol 41:432-440
Nelson, Kimberly J; Perkins, Arden; Van Swearingen, Amanda E D et al. (2018) Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid Redox Signal 28:521-536
Swanner, Jessica; Singh, Ravi (2018) Synthesis, Purification, Characterization, and Imaging of Cy3-Functionalized Fluorescent Silver Nanoparticles in 2D and 3D Tumor Models. Methods Mol Biol 1790:209-218
Holmila, Reetta J; Vance, Stephen A; Chen, Xiaofei et al. (2018) Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Rep 8:6635
Feliz-Mosquea, Yismeilin R; Christensen, Ashley A; Wilson, Adam S et al. (2018) Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy. Breast Cancer Res Treat 172:69-82

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