The over-arching goal of the Mass Spectrometry/Proteomics (MSP) Shared Facility is to provide UA B Cancer Center members with state-of-the-art capabilities and training in mass spectrometry, proteomics, and bioanalytic technologies to support their research needs. The MSP accomplishes this by providing services to UAB Cancer Center members to identify, characterize, and quantify proteins, protein post -translational modifications, lipids, and small molecules pre sent in cells, biological fluids, and tissues. T he MSP Shared Facility is organized into four modules: 1) Bioanalytical Separation and Sample Preparation, 2) Proteomics, 3) Small Molecule Analytics, and 4) Data Analysis and Bioinformatics The modules are supported by Master's level and Ph.D. scientists who are experts in mass spectrometry, bioanalytical chemistry, statistics, systems biology, and information handling. Cancer Center members utilize mass spectrometry and proteomic approaches in their individual and collaborative studies t hat range from the identification of disease biomarkers to the development of tools for structural biology.
The specific aims of this CCC sponsored shared facility are to: 1) Provide high-quality and cost-effective mass spectrometry and proteomics services to Cancer Center members including the identification and quantification of proteins, protein modification s, small molecules, lipids, drugs, and metabolites in complex biological samples and statistical and systems biology analyses of mass spectrometry/proteomics datasets; 2) Develop new approaches and integrate advances in state-of-the-art technologies to support cancer research;and 3) Provide training and education to UAB Cancer Center members through seminars, participation in formal graduate courses, web-based information, and individual or team meetings. The MSP has used highly innovative methods to find biomarkers for early stage pancreatic cancer; biomarkers for use in studies of diet-cancer interaction s;and to identify changes in ser um proteins in response to environmental chemicals such as bis-phenols, and markers of poor-prognosis breast cancer.
The ability to analyze proteins, lipids, and metabolites in complex biological samples provides critical insights into the action of chemotherapeutic drug;identification biological markers of disease diagnosis, progression, and therapeutic response;and changes in cellular pathways associated with malignant transformation. The MSP provides the specialized services critical to translating basic science discoveries to clinical applications in the treatment of cancer.
|Fauci, Janelle M; Sabbatino, Francesco; Wang, Yangyang et al. (2014) Monoclonal antibody-based immunotherapy of ovarian cancer: targeting ovarian cancer cells with the B7-H3-specific mAb 376.96. Gynecol Oncol 132:203-10|
|Carson, Tiffany L; Hardy, Claudia M; Greene, Eva et al. (2014) Considerations for bio-specimen collection among black women residing in the rural Deep South participating in a cancer prevention study. J Community Genet 5:257-63|
|Kim, Hyunki; Rigell, Christopher J; Zhai, Guihua et al. (2014) Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers. Mol Imaging Biol 16:85-94|
|Devine, D J; Rostas, J W; Metge, B J et al. (2014) Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-*/SMAD signaling. Oncogene 33:2620-8|
|Sonpavde, Guru; Willey, Christopher D; Sudarshan, Sunil (2014) Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma. Expert Opin Investig Drugs 23:305-15|
|Saini, Reshu; Hoyt, Kenneth (2014) Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis. Imaging Med 6:41-52|
|Shim, Eun-Hee; Livi, Carolina B; Rakheja, Dinesh et al. (2014) L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov 4:1290-8|
|Gan, Yujun; Buckels, Ashiya; Liu, Ying et al. (2014) Human GH receptor-IGF-1 receptor interaction: implications for GH signaling. Mol Endocrinol 28:1841-54|
|Johnson, David H; Wilson, W William; DeLucas, Lawrence J (2014) Protein solubilization: a novel approach. J Chromatogr B Analyt Technol Biomed Life Sci 971:99-106|
|Ramos, Theresa N; Bullard, Daniel C; Barnum, Scott R (2014) ICAM-1: isoforms and phenotypes. J Immunol 192:4469-74|
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