The over-arching goal of the Mass Spectrometry/Proteomics (MSP) Shared Facility is to provide UA B Cancer Center members with state-of-the-art capabilities and training in mass spectrometry, proteomics, and bioanalytic technologies to support their research needs. The MSP accomplishes this by providing services to UAB Cancer Center members to identify, characterize, and quantify proteins, protein post -translational modifications, lipids, and small molecules pre sent in cells, biological fluids, and tissues. T he MSP Shared Facility is organized into four modules: 1) Bioanalytical Separation and Sample Preparation, 2) Proteomics, 3) Small Molecule Analytics, and 4) Data Analysis and Bioinformatics The modules are supported by Master's level and Ph.D. scientists who are experts in mass spectrometry, bioanalytical chemistry, statistics, systems biology, and information handling. Cancer Center members utilize mass spectrometry and proteomic approaches in their individual and collaborative studies t hat range from the identification of disease biomarkers to the development of tools for structural biology.
The specific aims of this CCC sponsored shared facility are to: 1) Provide high-quality and cost-effective mass spectrometry and proteomics services to Cancer Center members including the identification and quantification of proteins, protein modification s, small molecules, lipids, drugs, and metabolites in complex biological samples and statistical and systems biology analyses of mass spectrometry/proteomics datasets; 2) Develop new approaches and integrate advances in state-of-the-art technologies to support cancer research;and 3) Provide training and education to UAB Cancer Center members through seminars, participation in formal graduate courses, web-based information, and individual or team meetings. The MSP has used highly innovative methods to find biomarkers for early stage pancreatic cancer; biomarkers for use in studies of diet-cancer interaction s;and to identify changes in ser um proteins in response to environmental chemicals such as bis-phenols, and markers of poor-prognosis breast cancer.

Public Health Relevance

The ability to analyze proteins, lipids, and metabolites in complex biological samples provides critical insights into the action of chemotherapeutic drug;identification biological markers of disease diagnosis, progression, and therapeutic response;and changes in cellular pathways associated with malignant transformation. The MSP provides the specialized services critical to translating basic science discoveries to clinical applications in the treatment of cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Kim, H-G; LeGrand, J; Swindle, C S et al. (2017) The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia. Leukemia 31:2267-2271
Miller, Aubrey L; Garcia, Patrick L; Pressey, Joseph G et al. (2017) Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors. Sci Rep 7:17787
Childers, Noel K; Grenett, Hernan; Morrow, Casey et al. (2017) Potential Risk for Localized Aggressive Periodontitis in African American Preadolescent Children. Pediatr Dent 39:294-298
Kasten, Benjamin B; Arend, Rebecca C; Katre, Ashwini A et al. (2017) B7-H3-targeted 212Pb radioimmunotherapy of ovarian cancer in preclinical models. Nucl Med Biol 47:23-30
Prince, Andrew C; Jani, Aditi; Korb, Melissa et al. (2017) Characterizing the detection threshold for optical imaging in surgical oncology. J Surg Oncol 116:898-906
McConnell, Matthew; Feng, Shengmei; Chen, Wei et al. (2017) Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity. Oncotarget 8:47675-47690
Kumar, Ranjit; Yi, Nengjun; Zhi, Degui et al. (2017) Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile. NPJ Biofilms Microbiomes 3:12
Van Beusecum, J P; Zhang, S; Cook, A K et al. (2017) Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour. Acta Physiol (Oxf) 221:204-220
Ghosh, Arindam P; Willey, Christopher D; Anderson, Joshua C et al. (2017) Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma. Oncotarget 8:29220-29232
Shah, Spandan; Gibson, Andrew W; Ji, Chuanyi et al. (2017) Regulation of FcR? function by site-specific serine phosphorylation. J Leukoc Biol 101:421-428

Showing the most recent 10 out of 692 publications