The objective of the Recruitment and Retention Shared Facility (RRSF) is to provide an infrastructure to recruit subjects to cancer control and therapeutic trials with expertise and emphasis on targeting minorities, women, and older individuals. To achieve this goal, the facility: 1) provides diverse recruitment services (developing recruitment strategies and materials;recruiting and scheduling subjects, etc.);2) provides the necessary linkage between CCC researchers and the surrounding communities;3) and maintains information systems with Recruitment Data Bases (RDB), Recruitment Tracking System (RTS), and Health Profile System (HPS) to identify subjects with health profiles of interest to investigators. Since its inception, the RRSF demonstrated success in recruiting participants primarily for large population-based clinical trials. More than 70,000 persons were recruited and screened for research studies; 23,103 participants were enrolled in 19 cancer studies;30% of these participants were African-American (a population of specific interest in our growing number of NIH-funded projects). More recent efforts focused on developing new strategies to recruit participants specifically for therapeutic clinical trials. An NCI-funded model program was implemented entitled """"""""Increasing Minority Participation in Clinical Trials"""""""" (IMPaCT) through Patient Navigation. IMPaCT aims to provide equal access to clinical trials for low-resource and minority patients by helping them overcome barriers to participation and move through the healthcare system. UAB is now the lead institution to provide training to implement the IMPaCT Patient Navigation program in five additional Cancer Centers with an emphasis on minority populations: the University of Minnesota, the University of Texas-MD Anderson, Johns Hopkins, and University of California-Davis. In addition, an IMPaCT Administrative Supplement was funded to extend the project to Cooper Green Mercy Hospital (CGMH), a county hospital that serves indigent patients in Birmingham. This project offers the opportunity to participate in clinical trials to CGMH patients who previously had no access to clinical trials, and the project forges new collaborations between CCC investigators and CGMH physicians. In addition, our experience with the IMPaCT Patient Navigation also resulted in a National Center on Minority Health and Health Disparities grant to create a national consortium to implement and evaluate new strategies to reduce health disparities by enhancing enrollment of minorities in cancer clinical trials. This national-level work rests upon the RRSF's continued success in providing excellent recruiting support for the UAB-CCC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013148-42
Application #
8738175
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
42
Fiscal Year
2014
Total Cost
$137,057
Indirect Cost
$63,251
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Kim, H-G; LeGrand, J; Swindle, C S et al. (2017) The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia. Leukemia 31:2267-2271
Miller, Aubrey L; Garcia, Patrick L; Pressey, Joseph G et al. (2017) Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors. Sci Rep 7:17787
Childers, Noel K; Grenett, Hernan; Morrow, Casey et al. (2017) Potential Risk for Localized Aggressive Periodontitis in African American Preadolescent Children. Pediatr Dent 39:294-298
Kasten, Benjamin B; Arend, Rebecca C; Katre, Ashwini A et al. (2017) B7-H3-targeted 212Pb radioimmunotherapy of ovarian cancer in preclinical models. Nucl Med Biol 47:23-30
Prince, Andrew C; Jani, Aditi; Korb, Melissa et al. (2017) Characterizing the detection threshold for optical imaging in surgical oncology. J Surg Oncol 116:898-906
McConnell, Matthew; Feng, Shengmei; Chen, Wei et al. (2017) Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity. Oncotarget 8:47675-47690
Kumar, Ranjit; Yi, Nengjun; Zhi, Degui et al. (2017) Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile. NPJ Biofilms Microbiomes 3:12
Van Beusecum, J P; Zhang, S; Cook, A K et al. (2017) Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour. Acta Physiol (Oxf) 221:204-220
Ghosh, Arindam P; Willey, Christopher D; Anderson, Joshua C et al. (2017) Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma. Oncotarget 8:29220-29232
Shah, Spandan; Gibson, Andrew W; Ji, Chuanyi et al. (2017) Regulation of FcR? function by site-specific serine phosphorylation. J Leukoc Biol 101:421-428

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