The primary objective of the Biostatistics and Bioinformatics Shared Facility (BBSF) is to provide centralized statistical services and collaborative research support for the research projects of the Cancer Center. To accomplish this, the BBSF has the following specific aims: 1) coordinate and manage statistical activities in the Cancer Center, ensuring that investigators have ready access to statistical consultation and support; 2) provide data analysis for Cancer Center projects using contemporary statistical methodologies; 3) provide statistical consultation on study design and research proposal development including pilot projects; 4) participate in teaching and training activities of the Cancer Center; 5) provide data management for the Clinical Protocol and Data Management (CPDM) Shared Facility including integration with OnCore; 6) develop and manage SPORE databases; 7) provide support for analysis of genetic data from UAB's Microarray Shared Facility and Hudson Alpha; 8) maintain a data and information computing system integrated with the Cancer Center's Data Sharing Plan; 9) develop methodologies for novel experimental designs and analyses that will enhance the BBSF's technical capabilities in providing collaborative research support. In addition to supporting the conventional needs of researchers, the BBSF has responded to the increasing role of multidimensional data analyses in mechanistic and functional studies using 'omic' technologies. The BBSF currently is composed of a team of faculty members and support staff from the Division of Preventive Medicine in the School of Medicine, and additional adjunct faculty from the Department of Biostatistics in the School of Public Health. By organizing as the BBSF they provide the Cancer Center investigators easy access to well-established and comprehensive biostatistical support in a very costeffective manner. The BBSF also has several integrative functions, as noted by the support for the SPOREfunded projects and the management of OnCore for the Clinical Protocol and Data Management (CPDM) Shared Facility. Importantly, the BBSF also serves as a continuous point of contact with our partners, Morehouse School of Medicine and Tuskegee University, by providing regular support and training in research design as part of the Cancer Partnership. The success of the facility is evident through the high volume of publications for which the BBSF provided key support in research design and statistical analyses.

Public Health Relevance

In order to provide the most valid results, research studies should begin with good experimental design, be well managed, and end with appropriate analysis for the data. The BBSF serves as the focal point from which cancer center investigators draw the necessary statistical expertise for the design, management and analysis of cancer research projects. Through this work, the BBSF helps the CCC to achieve its goals to improve cancer prevention and outcomes.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013148-43
Application #
8830230
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
43
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Jimenez, Rachel V; Wright, Tyler T; Jones, Nicholas R et al. (2018) C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. Front Immunol 9:372
Engle, Staci E; Antonellis, Patrick J; Whitehouse, Logan S et al. (2018) A CreER mouse to study melanin concentrating hormone signaling in the developing brain. Genesis 56:e23217
Van Arsdale, Anne R; Arend, Rebecca C; Cossio, Maria J et al. (2018) Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma. Cancer Med 7:616-625
Kim, Harrison (2018) Modification of population based arterial input function to incorporate individual variation. Magn Reson Imaging 45:66-71
Leath 3rd, Charles A; Monk, Bradley J (2018) Twenty-first century cervical cancer management: A historical perspective of the gynecologic oncology group/NRG oncology over the past twenty years. Gynecol Oncol 150:391-397
Park, Misun; Yoon, Young Sup (2018) Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes. Korean Circ J 48:974-988
Toboni, Michael D; Smith, Haller J; Bae, Sejong et al. (2018) Predictors of Unplanned Reoperation for Ovarian Cancer Patients From the National Surgical Quality Improvement Program Database. Int J Gynecol Cancer 28:1427-1431
Dionne-Odom, J Nicholas; Applebaum, Allison J; Ornstein, Katherine A et al. (2018) Participation and interest in support services among family caregivers of older adults with cancer. Psychooncology 27:969-976
Demark-Wahnefried, Wendy; Schmitz, Kathryn H; Alfano, Catherine M et al. (2018) Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin 68:64-89
Bandari, Shyam K; Purushothaman, Anurag; Ramani, Vishnu C et al. (2018) Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior. Matrix Biol 65:104-118

Showing the most recent 10 out of 747 publications