The Histology and Comparative Pathology Shared Resource of the Albert Einstein Cancer Center (AECC) provides comprehensive, expert, and cost-effective necropsy, histology and histopathology support to Center investigators. The facility, housed in the new Price Center, is highly utilized and provides a full range of histological services performed by experienced histotechnicians, including tissue preparation and processing, paraffin and frozen embedding and sectioning, standard and specialized histochemical stains, enzyme histochemistry, and immunohistochemistry-immunofluorescence. The facility is involved in translational studies utilizing human tissues and has a designated cryostat for cutting fresh frozen human samples for research. An important value-added service of the laboratory is the localized sectioning of frozen and paraffin embedded tissues to specific regions in the sample. Another specialized histology technique offered by the facility is the design and construction of customized tissue micro-arrays. The facility routinely trains users to perform various histology techniques such as paraffin and cryo-sectioning of tissues, immunohistochemistry, and laser capture microdissection. Complete gross and histological evaluation of tissues and animal models or genetically engineered mice is performed by Dr. Rani Sellers, DVM, PhD, DACVP. Dr. Sellers customarily trains investigators in tissue identification grossly and histologically. In addition to routine diagnostics. Dr. Sellers evaluates and troubleshoots histochemical and immunohistochemical stains, regularly writes reports, study methods, and results for manuscripts and grants, performs gross and histological photography for manuscripts, grants and presentations and helps develop and evaluate experimental protocols for animal studies. The facility is equipped with a desktop Oxford Scientific Hematology Analyzer for complete red and white blood cell parameters with differential white blood cell count to support the clinical pathology needs of AECC researchers. Clinical chemistry analytic services are in collaboration with the Analytical Core Laboratory affiliated with the Institute for Clinical and Translational Research at Einstein. The facility also houses a Leica laser capture microdissection system for the specific isolation of cell subsets within histological sections

Public Health Relevance

The Histology and Comparative Pathology Shared Resource provides comprehensive, expert, and costeffective necropsy, histology and histopathology services supporting the translational research mission and goals of the Albert Einstein Cancer Center (AECC). As an NCI-designated Cancer Center, AECC contributes to the national effort to reduce morbidity and mortality from cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA013330-40
Application #
8582096
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-06-01
Project End
2018-06-30
Budget Start
2013-08-23
Budget End
2014-06-30
Support Year
40
Fiscal Year
2013
Total Cost
$131,071
Indirect Cost
$51,765
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Oudin, Madeleine J; Hughes, Shannon K; Rohani, Nazanin et al. (2016) Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression. Clin Exp Metastasis 33:249-61
Lee, Chang-Hyun; Rimesso, Gerard; Reynolds, David M et al. (2016) Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster. G3 (Bethesda) 6:3207-3217
Lee, Kyeryoung; Tosti, Elena; Edelmann, Winfried (2016) Mouse models of DNA mismatch repair in cancer research. DNA Repair (Amst) 38:140-6
Díaz-Balzac, Carlos A; Rahman, Maisha; Lázaro-Peña, María I et al. (2016) Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites. Curr Biol 26:2379-87
Dam, Tarun K; Talaga, Melanie L; Fan, Ni et al. (2016) Measuring Multivalent Binding Interactions by Isothermal Titration Calorimetry. Methods Enzymol 567:71-95
Ito, Kyoko; Turcotte, Raphaël; Cui, Jinhua et al. (2016) Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354:1156-1160
Poulin, Myles B; Schneck, Jessica L; Matico, Rosalie E et al. (2016) Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36. Proc Natl Acad Sci U S A 113:1197-201
Yang, Chia-Ping Huang; Yap, Eng-Hui; Xiao, Hui et al. (2016) 2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes. Proc Natl Acad Sci U S A 113:11294-11299
Agalliu, Ilir; Gapstur, Susan; Chen, Zigui et al. (2016) Associations of Oral α-, β-, and γ-Human Papillomavirus Types With Risk of Incident Head and Neck Cancer. JAMA Oncol :
Epeldegui, Marta; Lee, Jeannette Y; Martínez, Anna C et al. (2016) Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial). Clin Cancer Res 22:328-36

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