The Cancer Epidemiology Program (CEP) is an interdisciplinary research program organized into three scientific areas, each related to a type of cancer risk factor: (1) Viral Risk Factors, (2) Hormonal, Obesity, and Inflammation- Related Risk Factors, and (3) Genetic and Epigenetic Risk Factors. Viral Risk Factor research in the CEP focuses extensively on human papillomavirus (HPV) and its role in anogenital and oral cancers. The CEP has long been a major contributor to HPV research. The goal of this research is to contribute new information important to the development of cancer screening practices, HPV vaccine strategies, and other new prevention and treatment methods. This includes studies of the viral and host factors associated with HPV persistence/progression;biomarkers of cervical and anal pre-cancer/cancer;the effectiveness of HPV vaccines in high risk populations;and the impact of microbicides on risk of HPV infection. In addition. Viral Risk Factor research in CEP addresses the effects of HIV/AIDS on cancer, including studies of the immunologic deficits that drive the relationship of HIV with HPV-related tumorigenesis and risk of other AIDS-associated cancers. Hormonal/Obesity/inflammation research in CEP focuses extensively on the role of the insulin/IGF-axis, sex hormones, adipocytokines, and related pathways in obesity-associated cancers (e.g., colon, breast, prostate, etc.). This includes prospective studies of tumor incidence/recurrence/progression and their relation with circulating and local tissue levels of proteins in these pathways and the expression of their receptors. Given the US obesity epidemic these studies are timely, and will contribute to ongoing efforts to identify biomarkers in these pathways that can be used for patient risk stratification, and/or as targets for chemoprevention and treatment. Genetic and Epigenetic research in CEP focuses extensively on germline and somatic mutations, genetic polymorphisms, DNA methylation, and microRNAs. These studies examine the signaling pathways related to oncogenesis, tumor biomarkers important for selecting and developing targeted therapies, and genetic/epigenetic risk factors that can be used for patient risk stratification. CEP investigators are also conducting methodologic studies to improve the laboratory and statistical tools available for conducting genetic and epigenetic research. The CEP currently has 26 members from 11 departments, of whom 11 are new members, supported by 15 NCI grants ($3.7M Direct), and 11 other peer-reviewed cancer-relevant grants ($2.7M Direct). Since the last CCSG review there have been 414 cancer-relevant research papers in the CEP of which 29% represent intraprogrammatic and 18% represent interprogrammatic publications.

Public Health Relevance

Members of this program study populations to identify risk factors for cancer in order to identify ways of preventing cancer. There is a special interest in: (i) viral infections that cause cancer such as the human papillomavirus that causes cervical cancer, (ii) the role of obesity and diabetes in cancer causation, and (iii) factors that increase the risk of breast cancer. These studies also provide valuable information relevant to the development of guidelines for screening.

National Institute of Health (NIH)
Center Core Grants (P30)
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Subcommittee B - Comprehensiveness (NCI)
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Albert Einstein College of Medicine
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Oudin, Madeleine J; Hughes, Shannon K; Rohani, Nazanin et al. (2016) Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression. Clin Exp Metastasis 33:249-61
Lee, Kyeryoung; Tosti, Elena; Edelmann, Winfried (2016) Mouse models of DNA mismatch repair in cancer research. DNA Repair (Amst) 38:140-6
Lee, Chang-Hyun; Rimesso, Gerard; Reynolds, David M et al. (2016) Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster. G3 (Bethesda) 6:3207-3217
Dam, Tarun K; Talaga, Melanie L; Fan, Ni et al. (2016) Measuring Multivalent Binding Interactions by Isothermal Titration Calorimetry. Methods Enzymol 567:71-95
Díaz-Balzac, Carlos A; Rahman, Maisha; Lázaro-Peña, María I et al. (2016) Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites. Curr Biol 26:2379-87
Poulin, Myles B; Schneck, Jessica L; Matico, Rosalie E et al. (2016) Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36. Proc Natl Acad Sci U S A 113:1197-201
Ito, Kyoko; Turcotte, Raphaël; Cui, Jinhua et al. (2016) Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354:1156-1160
Agalliu, Ilir; Gapstur, Susan; Chen, Zigui et al. (2016) Associations of Oral α-, β-, and γ-Human Papillomavirus Types With Risk of Incident Head and Neck Cancer. JAMA Oncol :
Yang, Chia-Ping Huang; Yap, Eng-Hui; Xiao, Hui et al. (2016) 2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes. Proc Natl Acad Sci U S A 113:11294-11299
Miskolci, Veronika; Wu, Bin; Moshfegh, Yasmin et al. (2016) Optical Tools To Study the Isoform-Specific Roles of Small GTPases in Immune Cells. J Immunol 196:3479-93

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