The increasing variety and complexity of analytic approaches and study designs utilized in cancer research necessitate the availability of an organized and centralized biostatistics resource that can offer a wide range of statistical expertise, collaboration, and training opportunities to investigators in the Albert Einstein Cancer Center (AECC). The Biostatistics Shared Resource (BSR) is staffed by experienced statisticians with proven track records of effective collaboration across all scientific programs and innovative research in many different methodologic areas. Given their broad knowledge of the scope of research activities within the AECC and numerous relationships with individual investigators, BSR personnel significantly enhance the Center infrastructure and environment and are ideally positioned to foster synergistic collaborations among members from different scientific disciplines. The specific objectives of the BSR are: ? To provide state-of-the-art statistical support on all phases of cancer research, from experimental design and study conduct to data analysis and manuscript preparation ? To collaborate on the development of methodologically rigorous grant applications and new research initiatives ? To assist with the development and scientific review of clinical trial protocols ? To develop innovative statistical approaches for new technologies in cancer research ? To offer a variety of training opportunities in statistical methods and to mentor junior investigators ? To enhance the AECC infrastructure and foster interdisciplinary collaborations via participation on scientific and administrative committees and interactions with other shared resources The overall goal in accomplishing these objectives is a robust, comprehensive and cost-effective system of statistical support for AECC investigators that contributes significantly to advancing our scientific understanding of different types of cancer and greater progress in the development of improved prevention detection, and treatment strategies.

Public Health Relevance

The Biostatistics Shared Resource provides a robust, comprehensive and cost-effective system of statistical support for Albert Einstein Cancer Center (AECC) investigators that contributes significantly to advancing our scientific understanding of different types of cancer and greater progress in the development of improved prevention, detection, and treatment strategies. As an NCI-designated Cancer Center, AECC contributes to the national effort to reduce morbidity and mortality from cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Albert Einstein College of Medicine
United States
Zip Code
Mao, Serena P H; Park, Minji; Cabrera, Ramon M et al. (2018) Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res 20:131
Mocholi, Enric; Dowling, Samuel D; Botbol, Yair et al. (2018) Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy. Cell Rep 24:1136-1150
Yang, Chia-Ping Huang; Wang, Changwei; Ojima, Iwao et al. (2018) Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of ?-Tubulin and the Multidrug Resistance Associated P-Glycoprotein. J Nat Prod 81:600-606
Guan, Fangxia; Tabrizian, Tahmineh; Novaj, Ardijana et al. (2018) Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis. Front Nutr 5:37
Wang, Tao; Hosgood, H Dean; Lan, Qing et al. (2018) The Relationship Between Population Attributable Fraction and Heritability in Genetic Studies. Front Genet 9:352
Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño, Leandro J et al. (2018) Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chem Biol 25:571-584.e8
Limi, Saima; Senecal, Adrien; Coleman, Robert et al. (2018) Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem 293:13176-13190
Rocha, Agostinho G; Franco, Antonietta; Krezel, Andrzej M et al. (2018) MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science 360:336-341
Cabahug-Zuckerman, Pamela; Stout Jr, Randy F; Majeska, Robert J et al. (2018) Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation. J Orthop Res 36:642-652
Vilchèze, Catherine; Copeland, Jacqueline; Keiser, Tracy L et al. (2018) Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy. MBio 9:

Showing the most recent 10 out of 1508 publications