This application seeks renewed CCSG funding for year 40 of the Albert Einstein Cancer Center (AECC) which received its first NCI designation in 1972. There are five established programs, including: (i) Tumor Microenvironment and Metastasis, led by John Condeelis, (ii) Stem Cells, Differentiation and Cancer, led by Richard Stanley, (iii) Experimental Therapeutics led by Susan Horwitz and Roman Perez-Soler), (iv) Cancer Epidemiology led by Thomas Rohan, and (v) The Biology of Colon Cancer, led by Leonard Augenlicht. There are thirteen established shared resources including: Analytical Imaging, Animal Barrier, Bioinformatics, Biostatistics, Centralized Protocol &Data Management Unit (CPDMU), Epidemiology Informatics, Flow Cytometry, Gene Targeting &Transgenic, Genomics, Histology and Comparative Pathology, Molecular Cytogenetic, Proteomics, and Structural Biology. Funding is requested for one new shared resource, Cancer Biospecimen Acquisition and Biorepository. In 2008, a major new research building was opened, the Price Center/Block Pavilion for Genetic and Translational Medicine, with more than half of that facility now occupied by AECC members and shared resources. An Einstein Stem Cell Institute was recently established adding a new dimension to the AECC research portfolio. There are currently 153 full AECC members. AECC research is supported by 82 NCI grants ($18.6 million direct) and 103 other cancer relevant peer-reviewed grants ($30.3 million direct).
;The Albert Einstein Cancer Center's mission is to develop a basic understanding of the causes of cancer and to apply that information to establish new approaches to the prevention, diagnosis, and treatment of cancer. This support Grant will provide the Albert Einstein Cancer Center with the infrastructure and resources to support the Center's research mission in order to contribute to the national effort to reduce the morbidity and mortality from cancer.
|Mao, Serena P H; Park, Minji; Cabrera, Ramon M et al. (2018) Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res 20:131|
|Mocholi, Enric; Dowling, Samuel D; Botbol, Yair et al. (2018) Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy. Cell Rep 24:1136-1150|
|Yang, Chia-Ping Huang; Wang, Changwei; Ojima, Iwao et al. (2018) Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of ?-Tubulin and the Multidrug Resistance Associated P-Glycoprotein. J Nat Prod 81:600-606|
|Guan, Fangxia; Tabrizian, Tahmineh; Novaj, Ardijana et al. (2018) Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis. Front Nutr 5:37|
|Wang, Tao; Hosgood, H Dean; Lan, Qing et al. (2018) The Relationship Between Population Attributable Fraction and Heritability in Genetic Studies. Front Genet 9:352|
|Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño, Leandro J et al. (2018) Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chem Biol 25:571-584.e8|
|Limi, Saima; Senecal, Adrien; Coleman, Robert et al. (2018) Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem 293:13176-13190|
|Rocha, Agostinho G; Franco, Antonietta; Krezel, Andrzej M et al. (2018) MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science 360:336-341|
|Cabahug-Zuckerman, Pamela; Stout Jr, Randy F; Majeska, Robert J et al. (2018) Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation. J Orthop Res 36:642-652|
|Vilchèze, Catherine; Copeland, Jacqueline; Keiser, Tracy L et al. (2018) Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy. MBio 9:|
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