The long-term goal of the Prostate Cancer (PC) Program is to elucidate the pathogenesis of prostate cancer and implement novel approaches to its prevention, early diagnosis, and individualized treatment. To achieve these ends, the following Specific Goals will be pursued: 1) The molecular oncology of prostate cancer will be elucidated by defining the molecular lesions of proto-oncogenes and tumor suppressor genes that are responsible for tumor formation;2) Experimental models of prostate cancer will be developed and characterized to elucidate critical regulatory networks, enhance preclinical studies, and define new biological endpoints, including the mechanisms of resistance to certain treatments; 3) The experimental therapeutics of prostate cancer will be refined by using molecular determinants to optimize clinical trials and thereby generate novel decision-making tools for disease management. The PC Program replaces the former Urologic Malignancies Program. It now consists of 19 members (12 full members, 4 clinical members, and 3 associate members) from 6 departments within the College of Physicians &Surgeons at Columbia University (CD). Compared to the Urologic Malignancies Program, the new PC Program has fewer members and their interests are more sharply focused on prostate cancer. New leadership has been brought into the Program, with Carlos Cordon-Cardo serving as Program Leader and Daniel Petrylak as Co-Leader. In the past ten months, major investments by the HICCC led to the recruitment of Dr. Cordon-Cardo, as well a several other outstanding basic and translational investigators, including Edward Gelmann, Cory Abate-Shen, and Michael Shen. The comprehensive nature of the restructured PC Program now ranges from chemoprevention to novel chemotherapy, surgical oncology including minimal invasive procedures, radiation therapy, and quality of care programs. The number of trials and the number of patients accrued to such trials have increased. Approximately 78% of clinical trial accruals are of African American or Hispanic ethnicity. Several investigators lead local and multi-center clinical trials. For the last budget year of the grant (July 1, 2006 - June 30, 2007), the PC Program received a total of $7.4M (direct costs) in cancer-relevant grant support, including $1.9M (direct costs) in NCI funding, $1.7M (direct costs) in other cancer-related peer-reviewed funding, and $3.8M (direct costs) in cancer-related non-peer-reviewed funding. The total number of publications since the previous submission was 172, of which 23% were intra-programmatic and 12% interprogrammatic.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
New York
United States
Zip Code
Bassuk, Alexander G; Sujirakul, Tharikarn; Tsang, Stephen H et al. (2014) A novel RPGR mutation masquerading as Stargardt disease. Br J Ophthalmol 98:709-11
Li, Yao; Wu, Wen-Hsuan; Hsu, Chun-Wei et al. (2014) Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects. Mol Ther 22:1688-97
Wert, Katherine J; Sancho-Pelluz, Javier; Tsang, Stephen H (2014) Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa. Hum Mol Genet 23:514-23
Shen, Sherry; Sujirakul, Tharikarn; Tsang, Stephen H (2014) Next-generation sequencing revealed a novel mutation in the gene encoding the beta subunit of rod phosphodiesterase. Ophthalmic Genet 35:142-50
Palomero, Teresa; Couronné, Lucile; Khiabanian, Hossein et al. (2014) Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet 46:166-70
Higuchi-Sanabria, Ryo; Pernice, Wolfgang M A; Vevea, Jason D et al. (2014) Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae. FEMS Yeast Res 14:1133-46
Lam, A T; Curschellas, C; Krovvidi, D et al. (2014) Controlling self-assembly of microtubule spools via kinesin motor density. Soft Matter 10:8731-6
Olszak, Torsten; Neves, Joana F; Dowds, C Marie et al. (2014) Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509:497-502
Murtomaki, Aino; Uh, Minji K; Kitajewski, Chris et al. (2014) Notch signaling functions in lymphatic valve formation. Development 141:2446-51
Nong, Eva; Lee, Winston; Merriam, Joanna E et al. (2014) Disease progression in autosomal dominant cone-rod dystrophy caused by a novel mutation (D100G) in the GUCA1A gene. Doc Ophthalmol 128:59-67

Showing the most recent 10 out of 142 publications