The Molecular Pathology Shared Resource (MPSR) is the largest shared resource of the Herbert Irving Comprehensive Cancer Center, serving 379 Pi's since 2007 and 193 Pi's this year (2013), with charge backs of ~$80K/month and 17,828 service requests fulfilled since 2007.
Its aim i s to facilitate tissue-based research so as to accelerate the realization of the great potential of the post-genomic era in cancer research. We provide our researchers a diverse set of services, including tumor banking, histology and immunohistochemistry, full pathological evaluation of human material and mouse models, traditional and """"""""next generation"""""""" (nucleic acids-based) tumor banking, as well as start-to-finish tissue-based research project management. Importantly, in close collaboration with the new Database SR, we help with data clawing (treatment, survival), data de-Identification and data storage, so that our banked material is well annotated and extremely valuable for clinical correlative studies. The MPSR has expanded its services recently to include whole slide scanning, storage and analysis (Leica SCN 400), high throughput RNA/DNA extraction capability (QIAsymphony SP), and fee-for-service project management, which is particularly valuable for clinicians who may not have their own research laboratory staff. Accordingly, the MPSR has played and continues to play a pivotal and ubiquitous role in enabling the HICCC research enterprise. The total operating budget of the facility is $1,193,178 of which we are requesting $ 118,178 from the CCSG

Public Health Relevance

The need to extract information from cancer and normal tissues has dramatically increased as high throughput technology and economically feasible TCGA-type multi-omic analysis, along with ever improving mouse models of cancer, are all bearing fruit. Our solutions are specifically geared to enable the full spectrum of basic and clinical cancer researchers to test their insights at the primary tissue level, efficiently and cost effectively, through ready access to tissue and RNA/DNA banks, services/expertise and associated technologies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA013696-40
Application #
8753132
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-07-04
Project End
2019-06-30
Budget Start
2014-07-17
Budget End
2015-06-30
Support Year
40
Fiscal Year
2014
Total Cost
$168,547
Indirect Cost
$63,205
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Hernandez, Celine; Huebener, Peter; Pradere, Jean-Philippe et al. (2018) HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest 128:2436-2451
Proto, Jonathan D; Doran, Amanda C; Gusarova, Galina et al. (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49:666-677.e6
Kraakman, Michael J; Liu, Qiongming; Postigo-Fernandez, Jorge et al. (2018) PPAR? deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects. J Clin Invest 128:2600-2612
Lee, Younghyun; Pujol Canadell, Monica; Shuryak, Igor et al. (2018) Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model. Sci Rep 8:13557
Evans, Lucy P; Newell, Elizabeth A; Mahajan, MaryAnn et al. (2018) Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice. Ann Clin Transl Neurol 5:240-251
Cui, Xuan; Jauregui, Ruben; Park, Karen Sophia et al. (2018) Multimodal characterization of a novel mutation causing vitamin B6-responsive gyrate atrophy. Ophthalmic Genet 39:512-516
Nathan, J; Ruscitto, A; Pylawka, S et al. (2018) Fibrocartilage Stem Cells Engraft and Self-Organize into Vascularized Bone. J Dent Res 97:329-337
Dieck, Chelsea L; Tzoneva, Gannie; Forouhar, Farhad et al. (2018) Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 34:136-147.e6
Sengillo, Jesse D; Lee, Winston; Bakhoum, Mathieu F et al. (2018) CHOROIDEREMIA ASSOCIATED WITH A NOVEL SYNONYMOUS MUTATION IN GENE ENCODING REP-1. Retin Cases Brief Rep 12 Suppl 1:S67-S71
Kratchmarov, Radomir; Viragova, Sara; Kim, Min Jung et al. (2018) Metabolic control of cell fate bifurcations in a hematopoietic progenitor population. Immunol Cell Biol 96:863-871

Showing the most recent 10 out of 331 publications