The Molecular Pathology Shared Resource (MPSR) is the largest shared resource of the Herbert Irving Comprehensive Cancer Center, serving 379 Pi's since 2007 and 193 Pi's this year (2013), with charge backs of ~$80K/month and 17,828 service requests fulfilled since 2007.
Its aim i s to facilitate tissue-based research so as to accelerate the realization of the great potential of the post-genomic era in cancer research. We provide our researchers a diverse set of services, including tumor banking, histology and immunohistochemistry, full pathological evaluation of human material and mouse models, traditional and """"""""next generation"""""""" (nucleic acids-based) tumor banking, as well as start-to-finish tissue-based research project management. Importantly, in close collaboration with the new Database SR, we help with data clawing (treatment, survival), data de-Identification and data storage, so that our banked material is well annotated and extremely valuable for clinical correlative studies. The MPSR has expanded its services recently to include whole slide scanning, storage and analysis (Leica SCN 400), high throughput RNA/DNA extraction capability (QIAsymphony SP), and fee-for-service project management, which is particularly valuable for clinicians who may not have their own research laboratory staff. Accordingly, the MPSR has played and continues to play a pivotal and ubiquitous role in enabling the HICCC research enterprise. The total operating budget of the facility is $1,193,178 of which we are requesting $ 118,178 from the CCSG
The need to extract information from cancer and normal tissues has dramatically increased as high throughput technology and economically feasible TCGA-type multi-omic analysis, along with ever improving mouse models of cancer, are all bearing fruit. Our solutions are specifically geared to enable the full spectrum of basic and clinical cancer researchers to test their insights at the primary tissue level, efficiently and cost effectively, through ready access to tissue and RNA/DNA banks, services/expertise and associated technologies.
|Bassuk, Alexander G; Zheng, Andrew; Li, Yao et al. (2016) Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells. Sci Rep 6:19969|
|Zhang, Lijuan; Du, Jianhai; Justus, Sally et al. (2016) Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest 126:4659-4673|
|Planet, Paul J; Parker, Dane; Cohen, Taylor S et al. (2016) Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection. MBio 7:e01939-15|
|Canetta, S; Bolkan, S; Padilla-Coreano, N et al. (2016) Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons. Mol Psychiatry 21:956-68|
|Joseph, Leroy C; Barca, Emanuele; Subramanyam, Prakash et al. (2016) Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes. PLoS One 11:e0145750|
|Gelman, Rony; Tsang, Stephen H (2016) SEQUENTIAL CENTRAL RETINAL VEIN AND OPHTHALMIC ARTERY OCCLUSIONS IN A PEDIATRIC CASE OF PRIMARY ANTIPHOSPHOLIPID SYNDROME. Retin Cases Brief Rep 10:58-62|
|Grillo, Lola M; Nguyen, Huy V; Tsang, Stephen H et al. (2016) Cobalt-Chromium Metallosis With Normal Electroretinogram. J Neuroophthalmol 36:383-388|
|Wert, Katherine J; Mahajan, Vinit B; Zhang, Lijuan et al. (2016) Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy. Signal Transduct Target Ther 1:|
|Moshfegh, Yasmin; Velez, Gabriel; Li, Yao et al. (2016) BESTROPHIN1 mutations cause defective chloride conductance in patient stem cell-derived RPE. Hum Mol Genet 25:2672-2680|
|Higuchi-Sanabria, Ryo; Swayne, Theresa C; Boldogh, Istvan R et al. (2016) Imaging of the Actin Cytoskeleton and Mitochondria in Fixed Budding Yeast Cells. Methods Mol Biol 1365:63-81|
Showing the most recent 10 out of 214 publications