The Biopolymers Division provides routine Sanger DNA sequencing in addition to next-generation genomic DNA sequencing (Illumine), peptide synthesis and purification, peptide arrays, basic mass spectrometry, high-pressure liquid chromatographic analysis and purification, and other services. The Proteomics Division provides services related to the identification, characterization, and quantitation of proteins from simple to complex mixtures. Approaches include the use of 1 D-gel, 2D-gel, or chromatographic fractionation methods followed by mass spectrometric analysis. Stable isotope derivatization and specialized software are available for quantitation of differential protein expression.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-42
Application #
8466729
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
42
Fiscal Year
2013
Total Cost
$283,368
Indirect Cost
$88,838
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Castellarnau, M; Szeto, G L; Su, H-W et al. (2015) Stochastic particle barcoding for single-cell tracking and multiparametric analysis. Small 11:489-98
Lunt, Sophia Y; Muralidhar, Vinayak; Hosios, Aaron M et al. (2015) Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell 57:95-107
Chan, Ka Man Carmen; Li, Randolph H; Chapman, Joseph W et al. (2014) Functionalizable hydrogel microparticles of tunable size and stiffness for soft-tissue filler applications. Acta Biomater 10:2563-73
Sukup-Jackson, Michelle R; Kiraly, Orsolya; Kay, Jennifer E et al. (2014) Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo. PLoS Genet 10:e1004299
Liu, Haipeng; Moynihan, Kelly D; Zheng, Yiran et al. (2014) Structure-based programming of lymph-node targeting in molecular vaccines. Nature 507:519-22
Murphy, Patrick A; Hynes, Richard O (2014) Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall. Arterioscler Thromb Vasc Biol 34:2042-50
Meira, Lisiane B; Calvo, Jennifer A; Shah, Dharini et al. (2014) Repair of endogenous DNA base lesions modulate lifespan in mice. DNA Repair (Amst) 21:78-86
Pallasch, Christian P; Leskov, Ilya; Braun, Christian J et al. (2014) Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell 156:590-602
Shlomai, Amir; Schwartz, Robert E; Ramanan, Vyas et al. (2014) Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Proc Natl Acad Sci U S A 111:12193-8
Mayers, Jared R; Wu, Chen; Clish, Clary B et al. (2014) Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med 20:1193-8

Showing the most recent 10 out of 309 publications