Koch Institute investigators rely heavily on the countless applications of flow cytometry to address the cellular basis of cancer development, progression, detection and treatment. The Flow Cytometry Core provides high end instrumentation and expert support to all cancer researchers Utilizing flow cytometry approaches. The Core is a full service flow cytometry resource, providing fee-based services including both individualized training and access to benchtop cytometers, and operator assisted high-speed cell sorting, and also expert guidance related to experimental design, fluorophore selection, data analysis, and experimental troubleshooting. In the current funding period, the Flow Cytometry Core has both increased and enhanced its instrumentation and also expanded its staff. These changes have greatly expanded the Core's capabilities while shortening turnaround times and increasing the service output. The Flow Cytometry Core has an outstanding and knowledgeable staff that provides Kl investigators with cutting-edge technical expertise. By establishing this expensive and technically challenging technology as a shared resource, the Core provides Kl Investigators with a comprehensive and reliable range of services. With continued growth in service demand, the Core will further expand its offerings for the requested funding period, enabling new experimental applications while still maintaining reasonable wait times for instrument access.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-42
Application #
8466731
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
42
Fiscal Year
2013
Total Cost
$203,245
Indirect Cost
$88,838
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Gocheva, Vasilena; Naba, Alexandra; Bhutkar, Arjun et al. (2017) Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. Proc Natl Acad Sci U S A 114:E5625-E5634
Roper, Jatin; Tammela, Tuomas; Cetinbas, Naniye Malli et al. (2017) In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol 35:569-576
Castleberry, Steven A; Quadir, Mohiuddin A; Sharkh, Malak Abu et al. (2017) Polymer conjugated retinoids for controlled transdermal delivery. J Control Release 262:1-9
Fenouille, Nina; Bassil, Christopher F; Ben-Sahra, Issam et al. (2017) The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nat Med 23:301-313
Chen, Tiffany F; Sazinsky, Stephen L; Houde, Damian et al. (2017) Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs. J Mol Biol 429:2528-2541
Lippok, Norman; Villiger, Martin; Albanese, Alexandre et al. (2017) Depolarization signatures map gold nanorods within biological tissue. Nat Photonics 11:583-588
Suzuki, Hiroshi I; Young, Richard A; Sharp, Phillip A (2017) Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell 168:1000-1014.e15
Doloff, Joshua C; Veiseh, Omid; Vegas, Arturo J et al. (2017) Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater 16:671-680
Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine et al. (2017) Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science 355:
Gu, Li; Deng, Zhou J; Roy, Sweta et al. (2017) A Combination RNAi-Chemotherapy Layer-by-Layer Nanoparticle for Systemic Targeting of KRAS/P53 with Cisplatin to Treat Non-Small Cell Lung Cancer. Clin Cancer Res 23:7312-7323

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