The Developmental Funds at this CCSG are also used to fund pilot projects in new research directions. The ability to provide funding for pilot projects is a highly effective mechanism for the Director and Program Leaders to influence the progress of cancer research at MIT and to rapidly respond to new opportunities and new strategic directions. It also represents a means to bring different Kl members together in collaborative projects. Pilot projects are expected to be novel and eariy-stage. They are often high risk/high reward in nature, and it is anticipated that the funding will allow for the generation of preliminary data that might form the basis of future grant applications. During the past grant period, eight pilot projects were selected for funding. Funds were awarded to projects in years 32, 34 and 37. Due to budget reductions in the CCSG, we were able to support fewer pilot projects than originally planned. However, as described below, projects that were funded have led to a series of very interesting observations, several publications and some new grant applications. In the current application, we are seeking funds sufficient to support 3 pilot projects annually. As is currentiy the case, applications will be reviewed by the Kl Director and a committee of faculty and awarded on the basis of both the quality of the application and on the novelty of the approaches proposed. Program leaders are encouraged to stimulate new directions of research within their Programs by encouraging their members to apply for pilot project funding;they also help to organize intra- and inter-programmatic collaborations. As has been true in the past, we anticipate that this mechanism will be very effective in assisting Kl members to embark on innovative research projects with potential for a significant impact on cancer diagnosis, treatment and control. With the introduction of the Koch Clinical Investigators Program as well as increased interactions with local clinical centers, there is an increased opportunity for clinically-oriented pilot projects.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts Institute of Technology
United States
Zip Code
Castellarnau, M; Szeto, G L; Su, H-W et al. (2015) Stochastic particle barcoding for single-cell tracking and multiparametric analysis. Small 11:489-98
Lunt, Sophia Y; Muralidhar, Vinayak; Hosios, Aaron M et al. (2015) Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell 57:95-107
Liu, Haipeng; Moynihan, Kelly D; Zheng, Yiran et al. (2014) Structure-based programming of lymph-node targeting in molecular vaccines. Nature 507:519-22
Chan, Ka Man Carmen; Li, Randolph H; Chapman, Joseph W et al. (2014) Functionalizable hydrogel microparticles of tunable size and stiffness for soft-tissue filler applications. Acta Biomater 10:2563-73
Sukup-Jackson, Michelle R; Kiraly, Orsolya; Kay, Jennifer E et al. (2014) Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo. PLoS Genet 10:e1004299
Pallasch, Christian P; Leskov, Ilya; Braun, Christian J et al. (2014) Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell 156:590-602
Murphy, Patrick A; Hynes, Richard O (2014) Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall. Arterioscler Thromb Vasc Biol 34:2042-50
Meira, Lisiane B; Calvo, Jennifer A; Shah, Dharini et al. (2014) Repair of endogenous DNA base lesions modulate lifespan in mice. DNA Repair (Amst) 21:78-86
Labelle, Myriam; Begum, Shahinoor; Hynes, Richard O (2014) Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci U S A 111:E3053-61
Shlomai, Amir; Schwartz, Robert E; Ramanan, Vyas et al. (2014) Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Proc Natl Acad Sci U S A 111:12193-8

Showing the most recent 10 out of 309 publications