Through collaboration, training and technical assistance, the Kl Bioinformafics &Computing Core (BCC) Facility ensures that Kl researchers and other Kl Core Facilities are positioned to fully utilize the power of bioinformafics and statistics in their research. In the previous period, the BCC has both evolved and expanded its services to respond to the rapid advances and growing demand for computation capabilifies. The BCC provides Kl researchers with bioinformatics expertise in protein and genome sequence analysis and annotation, analysis of a variety of different microarray applicafions and interpretation of data from next generafion sequencing. In addifion, the Core provides the desktop and server-based IT services required to support the data-intensive technologies and applications essential for modern cancer research. In these capacities, the BCC has contributed to the projects of more than 85 researchers in the current funding period. The BCC is staffed by outstanding scientists who are expert in a wide array of computational methodologies and have an established track record for acquiring or developing new approaches. They also offer expert training to help Kl investigators develop their own bioinformafics skills. In the upcoming period, the BCC will confinue its support of a wide range of bioinformafics methods while expanding both scientific and IT capabilities in response to the rapid development of new technologies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-43
Application #
8680156
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
43
Fiscal Year
2014
Total Cost
$212,179
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Weidberg, Hilla; Amon, Angelika (2018) MitoCPR-A surveillance pathway that protects mitochondria in response to protein import stress. Science 360:
Chiu, Anthony C; Suzuki, Hiroshi I; Wu, Xuebing et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Mol Cell 69:648-663.e7
Nagarajan, Maxwell B; Tentori, Augusto M; Zhang, Wen Cai et al. (2018) Nonfouling, Encoded Hydrogel Microparticles for Multiplex MicroRNA Profiling Directly from Formalin-Fixed, Paraffin-Embedded Tissue. Anal Chem 90:10279-10285
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Suarez-Lopez, Lucia; Sriram, Ganapathy; Kong, Yi Wen et al. (2018) MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A 115:E4236-E4244
Guner-Ataman, Burcu; González-Rosa, Juan Manuel; Shah, Harsh N et al. (2018) Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome. Cell Rep 24:1342-1354.e5
Phizicky, David V; Berchowitz, Luke E; Bell, Stephen P (2018) Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis. Elife 7:

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