The mission of the Shared Research Resources (SRR) Core Facility is to maintain the infrastructural underpinnings of all aspects of the Koch Institute's research program. This Core differs from all other Core Facilities in that it does not have a specific locafion but instead functions building-wide. The Core has several key responsibilities. First, it oversees the smooth running of the Kl building, interfacing with MIT's physical plant to address any emerging issues. This includes overseeing maintenance of cold rooms, warm rooms, fissue culture rooms and darkrooms. Second, the Core provides, supports and maintains a wide range of distributed equipment that is used as a shared resource by the Core Facilities and/or the researchers in the Kl building. Third, it supports the comprehensive Environment, Health & Safety management system (EHS-MS) developed by MIT in compliance with federal, state and local regulafions. In this capacity, the Core provides safety inspections, laboratory safety, staff training and hazardous waste management to investigator laboratories and Core Facilifies. Finally, the SRR Core oversees dedicated research spaces in the Kl building that have been developed to provide oversight of, and enable safe working pracfices with, certain high titer VSVg-pseiJdotyped viruses, high-risk isotopes, and the cesium g-cell radiation source essential of our research programs. As oufiined below, much of the cost of the SRR Core's activity is supported direcfiy by MIT. However, CCSG funds provide crifical contributions towards the partial salary support of the SRR Core personnel and central services.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-43
Application #
8680165
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
43
Fiscal Year
2014
Total Cost
$130,956
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Roper, Jatin; Tammela, Tuomas; Cetinbas, Naniye Malli et al. (2017) In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol 35:569-576
Gocheva, Vasilena; Naba, Alexandra; Bhutkar, Arjun et al. (2017) Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. Proc Natl Acad Sci U S A 114:E5625-E5634
Fenouille, Nina; Bassil, Christopher F; Ben-Sahra, Issam et al. (2017) The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nat Med 23:301-313
Castleberry, Steven A; Quadir, Mohiuddin A; Sharkh, Malak Abu et al. (2017) Polymer conjugated retinoids for controlled transdermal delivery. J Control Release 262:1-9
Lippok, Norman; Villiger, Martin; Albanese, Alexandre et al. (2017) Depolarization signatures map gold nanorods within biological tissue. Nat Photonics 11:583-588
Chen, Tiffany F; Sazinsky, Stephen L; Houde, Damian et al. (2017) Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs. J Mol Biol 429:2528-2541
Doloff, Joshua C; Veiseh, Omid; Vegas, Arturo J et al. (2017) Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater 16:671-680
Suzuki, Hiroshi I; Young, Richard A; Sharp, Phillip A (2017) Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell 168:1000-1014.e15
Gu, Li; Deng, Zhou J; Roy, Sweta et al. (2017) A Combination RNAi-Chemotherapy Layer-by-Layer Nanoparticle for Systemic Targeting of KRAS/P53 with Cisplatin to Treat Non-Small Cell Lung Cancer. Clin Cancer Res 23:7312-7323
Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine et al. (2017) Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science 355:

Showing the most recent 10 out of 829 publications