The Animal Imaging & Preclinical Testing Core (AIPT Core) is a critical Shared Resource in the Koch Institute?s mission of combining the strengths of discovery cancer research and engineering-based technology development to advance the diagnosis and treatment of cancer. The AIPT Core supports the detection, characterization and therapeutic treatment of tumors in live animals to enable: (i) elucidation of the mechanisms of tumor development and metastasis; (ii) analysis of chemotherapeutic response and resistance; and (iii) the evaluation of novel therapeutic approaches, drug delivery systems, and tumor detection and monitoring devices. The AIPT Core (previously known as the Applied Therapeutics & Whole Animal Imaging Core) was approved for CCSG funding as a new Shared Resource in 2009 with a limited budget because of the nascent nature of this effort. During the current period, usage of the AIPT Core increased dramatically and now 47% of CCSG Members (representing all four programs) rely on the AIPT Core?s services. To support this demand, the Core?s capabilities have been greatly expanded and enhanced using non-renewable MIT funds. This includes: moving into new space that is custom-designed to enable longitudinal imaging and preclinical testing in mouse models; the acquisition of extensive new imaging instrumentation, including small animal MRI and MRS; and a significant expansion of the staff. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, the AIPT Core will continue to offer a wide range of animal imaging and pre-clinical services to support the research programs of Center Members. To stabilize the staff salaries in this now fully established Core, and allow addition of an MRI specialist, a significant increase in the AIPT Core CCSG budget is requested.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-46
Application #
9282614
Study Section
Subcommittee A - Cancer Centers (NCI-A)
Project Start
Project End
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
46
Fiscal Year
2017
Total Cost
$174,801
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Domestic Higher Education
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02142
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