The scientific goals and central themes of the Growth Control and Genomic Stability Program are to understand mechanisms of proliferation and cell size regulation, transcriptional regulation of oncogenic signaling pathways, DMA damage response, maintenance of genomic integrity and telomere function, and how these processes are disrupted in cancer cells. The program includes ten members from six different laboratories: Beverly Emerson (transcriptional regulation by the p53 tumor suppressor), Martin Hetzer (nuclear pore assembly mechanisms and cancer), Katherine Jones (Wnt/p-catenin signaling pathways and transcriptional regulation), Jan Karlseder (telomere function and dysregulation in cancer cells), Vicki Lundblad (telomere regulation in yeast), Clodagh O'Shea (oncolytic adenoviruses and adenovirus-targeted proliferation pathways), James Umen (RB pathway*"""""""" regulation and cell size in Chlamydomonas), Geoffrey Wahl (p53 stress response pathway), Lei Wang (unnatural amino acid incorporation in tumor cells and stem cells), and Matthew Weitzman (host cell DNA damage response systems abrogated by viruses). The total amount of peer-reviewed support (direct costs) for the last budget year was $3,325,741. Of this amount, $920,040 was awarded by the NCI. The total number of publications by members of this program in the last grant period (2004-2008) was 132. Of the total publications, 3% were intraprogrammatic and 11% were interprogrammatic (see Section 8 for explanation of how the program reorganization affects these numbers).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014195-40
Application #
8463955
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
40
Fiscal Year
2013
Total Cost
$22,045
Indirect Cost
$10,406
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Mertens, Jerome; Marchetto, Maria C; Bardy, Cedric et al. (2016) Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci 17:424-37
Zheng, Xinde; Boyer, Leah; Jin, Mingji et al. (2016) Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife 5:
Lacar, Benjamin; Linker, Sara B; Jaeger, Baptiste N et al. (2016) Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun 7:12020
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Shen, Run; Wang, Biao; Giribaldi, Maria G et al. (2016) Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. Proc Natl Acad Sci U S A 113:E3307-14
Ma, Jiao; Diedrich, Jolene K; Jungreis, Irwin et al. (2016) Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides. Anal Chem 88:3967-75
Liu, Wen-Hsien; Kang, Seung Goo; Huang, Zhe et al. (2016) A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. J Exp Med 213:1901-19
Xu, Jiqing; de Winter, Fred; Farrokhi, Catherine et al. (2016) Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep 6:31692
Ibarra, Arkaitz; Benner, Chris; Tyagi, Swati et al. (2016) Nucleoporin-mediated regulation of cell identity genes. Genes Dev 30:2253-2258
Chinen, Takatoshi; Kannan, Arun K; Levine, Andrew G et al. (2016) An essential role for the IL-2 receptor in Treg cell function. Nat Immunol 17:1322-1333

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