The Proteomics Core Facility was developed as shared resource with Developmental funds in the previous funding period. It was reviewed as an established core in the 2008 competitive renewal and received an assessment of Outstanding Merit. The Facility, which is equipped with two mass spectrometers, performs proteomic analyses for members of the Cancer Center using Mass spectrometry. Services of the Facility include characterization of synthetic peptides and phosphopeptides, identification of proteins, and analysis of protein modifications.

Public Health Relevance

Cancer, caused by changes in genes, translates into changes in proteins and their function. This resource breaks proteins down into segments (peptides) to analyze changes in proteins at the level of their individual amino acid components.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA014195-41
Application #
8934274
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ciolino, Henry P
Project Start
2013-12-01
Project End
2018-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
41
Fiscal Year
2014
Total Cost
$412,394
Indirect Cost
$201,274
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Mertens, Jerome; Marchetto, Maria C; Bardy, Cedric et al. (2016) Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci 17:424-37
Zheng, Xinde; Boyer, Leah; Jin, Mingji et al. (2016) Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife 5:
Lacar, Benjamin; Linker, Sara B; Jaeger, Baptiste N et al. (2016) Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun 7:12020
Kolar, Matthew J; Kamat, Siddhesh S; Parsons, William H et al. (2016) Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry 55:4636-41
Shen, Run; Wang, Biao; Giribaldi, Maria G et al. (2016) Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. Proc Natl Acad Sci U S A 113:E3307-14
Ma, Jiao; Diedrich, Jolene K; Jungreis, Irwin et al. (2016) Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides. Anal Chem 88:3967-75
Liu, Wen-Hsien; Kang, Seung Goo; Huang, Zhe et al. (2016) A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. J Exp Med 213:1901-19
Xu, Jiqing; de Winter, Fred; Farrokhi, Catherine et al. (2016) Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep 6:31692
Ibarra, Arkaitz; Benner, Chris; Tyagi, Swati et al. (2016) Nucleoporin-mediated regulation of cell identity genes. Genes Dev 30:2253-2258
Chinen, Takatoshi; Kannan, Arun K; Levine, Andrew G et al. (2016) An essential role for the IL-2 receptor in Treg cell function. Nat Immunol 17:1322-1333

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