The Proteomics Core Facility was developed as shared resource with Developmental funds in the previous funding period. It was reviewed as an established core in the 2008 competitive renewal and received an assessment of Outstanding Merit. The Facility, which is equipped with two mass spectrometers, performs proteomic analyses for members of the Cancer Center using Mass spectrometry. Services of the Facility include characterization of synthetic peptides and phosphopeptides, identification of proteins, and analysis of protein modifications.
Cancer, caused by changes in genes, translates into changes in proteins and their function. This resource breaks proteins down into segments (peptides) to analyze changes in proteins at the level of their individual amino acid components.
|Aslanian, Aaron; Yates 3rd, John R; Hunter, Tony (2014) Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells. DNA Repair (Amst) 15:29-38|
|Lew, Erin D; Oh, Jennifer; Burrola, Patrick G et al. (2014) Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. Elife 3:|
|Chaix, Amandine; Zarrinpar, Amir; Miu, Phuong et al. (2014) Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab 20:991-1005|
|Xia, Yifeng; Shen, Shen; Verma, Inder M (2014) NF-?B, an active player in human cancers. Cancer Immunol Res 2:823-30|
|Islam, Md Soriful; Catherino, William H; Protic, Olga et al. (2014) Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function. J Clin Endocrinol Metab 99:E775-85|
|Evans, Ronald M; Mangelsdorf, David J (2014) Nuclear Receptors, RXR, and the Big Bang. Cell 157:255-66|
|Liu, Guang-Hui; Suzuki, Keiichiro; Li, Mo et al. (2014) Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nat Commun 5:4330|
|Buchwalter, Abigail L; Liang, Yun; Hetzer, Martin W (2014) Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol Biol Cell 25:2472-84|
|Hatori, Megumi; Gill, Shubhroz; Mure, Ludovic S et al. (2014) Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife 3:e03357|
|Korf, Katharina; Wodrich, Harald; Haschke, Alexander et al. (2014) The PML domain of PML-RAR? blocks senescence to promote leukemia. Proc Natl Acad Sci U S A 111:12133-8|
Showing the most recent 10 out of 105 publications