Functional Genomics and Genome Sequencing Core Shared Resource - Project Summary/Abstract The mission of the Functional Genomics and Genome Sequencing Core is to facilitate cutting-edge genomics research at the Salk Institute by providing: 1) cost-effective and rapid high-throughput sequencing services, 2) expert assistance in experimental design, and 3) the development of novel methods to enable cutting edge sequencing technologies. In addition, the Core prepares sequencing libraries and performs quality control to ensure that high-quality data are extracted from each experimental sample. In the near future, the Core will acquire and implement a single cell sequencing platform. In support of Cancer Center research endeavors at the Salk, the Core specifically aims to provide: 1) access to state-of-the-art instrumentation for next-generation sequencing projects, 2) assistance with experimental design when Salk Cancer Center members are seeking to perform experiments that involve sequencing technologies, 3) novel methods and strategies for implementing cutting-edge sequencing technologies, 4) preparation and quality control of sequencing libraries, and 5) training services for Cancer Center members in library preparation or other methods required for next- generation sequencing projects.
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| Ma, Jiao; Saghatelian, Alan; Shokhirev, Maxim Nikolaievich (2018) The influence of transcript assembly on the proteogenomics discovery of microproteins. PLoS One 13:e0194518 |
| Patriarchi, Tommaso; Cho, Jounhong Ryan; Merten, Katharina et al. (2018) Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors. Science 360: |
| Kolar, Matthew J; Nelson, Andrew T; Chang, Tina et al. (2018) Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem 90:5358-5365 |
| Ogawa, Junko; Pao, Gerald M; Shokhirev, Maxim N et al. (2018) Glioblastoma Model Using Human Cerebral Organoids. Cell Rep 23:1220-1229 |
| Ahmadian, Maryam; Liu, Sihao; Reilly, Shannon M et al. (2018) ERR? Preserves Brown Fat Innate Thermogenic Activity. Cell Rep 22:2849-2859 |
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| Yoon, Young-Sil; Tsai, Wen-Wei; Van de Velde, Sam et al. (2018) cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. Proc Natl Acad Sci U S A 115:E5289-E5297 |
| Xia, Yifeng; Zhan, Cheng; Feng, Mingxiang et al. (2018) Targeting CREB Pathway Suppresses Small Cell Lung Cancer. Mol Cancer Res 16:825-832 |
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