The Cancer Biology Program was developed in recognition that cancer is a disease that extends beyond the cancer cell itself, with the goal of promoting studies on the molecular mechanisms of cancer in the context of the whole body. Because of the complex nature of cancer when viewed as a disease of the body, the Cancer Biology Program unites and supports current and future scientists of different disciplines. To achieve this goal, the Cancer Biology program is partitioned into three overiapping focus groups 1) Molecular Tumorigenesis: overseen by Drs. Gerry Blobe, Chris Counter, and Ann Marie Pendergast and is focused on studying the molecular mechanisms of tumorigenesis in vivo. 2) Cancer Stem Cell Biology: overseen by Drs. Brigid Hogan and Tannishtha Reya and is focused on understanding the role of stem cells in cancer, as well as how to exploit their capacity to maintain healthy tissues and to replace cells lost by disease or injury. 3) Cancer Immunobiology: overseen by Drs. Timothy Clay and H. Kim Lyerly and is focused on studying immunological aspects of cancer biology and treatment. Together these three focus groups encompass the major disciplines of in vivo cancer biology. The Program includes 37 members from 10 basic and clinical departments within Duke University. Total funding for program members is $25,439,989, of which $21,769,175 is from peer- reviewed sources. A cancer focus is illustrated by $6,211,085 or 28.5% of funding from the NCI, the American Cancer Society or the Department of Defense. From 2004-2008, program members published 625 papers in peer-reviewed journals cited in PubMed. Of these publications, 10% are the result of intra-programmatic collaborations and 19% due to inter-programmatic collaborations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-38
Application #
8379530
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-01-01
Budget End
2012-12-31
Support Year
38
Fiscal Year
2012
Total Cost
$28,375
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Galaz-Montoya, Monica; Wright, Sara J; Rodriguez, Gustavo J et al. (2017) ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem 292:9967-9974
Lanier, Megan L; Park, Hyeri; Mukherjee, Paramita et al. (2017) Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation. Chemistry 23:7180-7184
Shi, Qiong; Liu, Hongliang; Han, Peng et al. (2017) Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. J Invest Dermatol 137:1749-1756
Woyach, Jennifer A; Ruppert, Amy S; Guinn, Daphne et al. (2017) BTKC481S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia. J Clin Oncol 35:1437-1443
Wang, Yanru; Freedman, Jennifer A; Liu, Hongliang et al. (2017) Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer. Int J Cancer 141:731-743
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Leu, David; Spasojevic, Ivan; Nguyen, Huy et al. (2017) CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. Redox Biol 12:864-871
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Pan, Yongchu; Liu, Hongliang; Wang, Yanru et al. (2017) Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep 7:44634
Yin, Jieyun; Liu, Hongliang; Liu, Zhensheng et al. (2017) Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Mol Carcinog 56:1663-1672

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