The Duke Biorepository was placed under central development and control in the year 2000 and continues to focus on the demands of contemporary investigators on tissue procurement. Over 10,000 patient consents, 5,000 banking events, and 40,000 biospecimens have been processed to date with storage of both formalin fixed paraffin embedded (FFPE) tissue and frozen tissue located within multiple freezers spanning temperatures in the range of -80 to -180 C depending on protocol requirements. Considerable effort confinues to be expended to assure compliance with IRB, NIH and HIPAA best pradices arid guidelines on banking human tissues. The biorepository in place today is the result of the combined efforts of the Duke Comprehensive Cancer Institute (DCCI) Breast SPORE, DCCI Shared Resource for Tissue and Blood Procurement, and the Duke University School of Medicine Research Foundafion (DUSOM-RF). The biorepository has been steadily collecting frozen and formalin-fixed paraffin embedded samples following standard operafing procedures established at the outset and meefing a high level of quality standards. The DCCI and the School of Medicine Research Foundation (SOMRF) have funded the collection of frozen and fixed fissues, both malignant and benign, under an "excess fissue" protocol that utilizes freshly excised tissue that is available for research after the needs of the pathologic workup are met. This program procures fissues from many anatomic sites including breast. Recently Duke's Institute of Genome Science and Policy (IGSP), under the direction of Drs. Geoff Ginsburg and Tom Burke, inifiated a blood collection program that spans several departments and institutes. The Breast SPORE blood collection program served as the pilot for this much larger effort. The Breast SPORE tissue and blood collection effort utilizes much of the same infrastructure and personnel that are also supported by the DCCI, SOMRF, and IGSP. The Breast SPORE has served as the model for other recent tissue banking initiatives at Duke. The Duke biorepository has maintained a high level of operational and data management integrity utilizing standardized operating procedures and a robust informatics platform, entitled MAW3. Existing infrastructure and resources continue to be ufilized to their maximum potenfial to minimize addifional costs. Expansion of blood collecfions and further collaborafions with Cancer Institute clinical trials activifies is planned.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-40
Application #
8601847
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
40
Fiscal Year
2014
Total Cost
$91,744
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Adams, Rebecca N; Mosher, Catherine E; Blair, Cindy K et al. (2015) Cancer survivors' uptake and adherence in diet and exercise intervention trials: an integrative data analysis. Cancer 121:77-83
Pruszynski, Marek; Koumarianou, Eftychia; Vaidyanathan, Ganesan et al. (2014) Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling. J Nucl Med 55:650-6
Batinic-Haberle, Ines; Tovmasyan, Artak; Roberts, Emily R H et al. (2014) SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal 20:2372-415
Sachdeva, Mohit; Mito, Jeffrey K; Lee, Chang-Lung et al. (2014) MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. J Clin Invest 124:4305-19
Tovmasyan, Artak; Carballal, Sebastian; Ghazaryan, Robert et al. (2014) Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents. Inorg Chem 53:11467-83
Azrad, Maria; Demark-Wahnefried, Wendy (2014) The association between adiposity and breast cancer recurrence and survival: A review of the recent literature. Curr Nutr Rep 3:9-15
Blair, Cindy K; Madan-Swain, Avi; Locher, Julie L et al. (2013) Harvest for health gardening intervention feasibility study in cancer survivors. Acta Oncol 52:1110-8
Mito, Jeffrey K; Min, Hooney D; Ma, Yan et al. (2013) Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. J Pathol 229:132-40
Pruszynski, Marek; Koumarianou, Eftychia; Vaidyanathan, Ganesan et al. (2013) Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. Nucl Med Biol 40:52-9
Hover, Bradley M; Loksztejn, Anna; Ribeiro, Anthony A et al. (2013) Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis. J Am Chem Soc 135:7019-32

Showing the most recent 10 out of 161 publications