The High Resolution NMR Shared Resource provides access to and technical support for over $6M worth of state-of-the-art instrumentation essential for modern magnetic resonance spectroscopy, and links to the NMR Facility at the North Carolina Research Campus in Kannapolis, NC, which has the only 950MHz Bruker instrument in the United States. The Shared Resource has gained a worldwide reputation for being active in the design and implementation of new methodologies in biological NMR and stable isotope labeling techniques, which are routinely brought to bear to advance DCI members' research. The Resource's expert staff train and assist users in both the fundamentals and the most modern and advanced applications of powerful NMR technologies. The group supports the research instrumentation needs of a variety of DCI areas and programs. Support for this resource comes from a combination of institutional funding, Cancer Center Support Grant funding, and user fees. A combination of institutional and external funding are used to support equipment purchases and upgrades in order to ensure availability of the highest performing NMR instrumentation to all DCI members. Over the past year, of the 29 active user groups of the NMR Shared Resource, 16 (55%) are members of the DCI. Of these 16, 14 have active peer reviewed funding. Our DCI users represent five of the nine DCI programs: Developmental Therapeutics, Neuro-Oncology, Cancer Genetics and Genomics, Cancer Control and Population Sciences, and Hematologic Malignancies and Cellular Therapies. The long-term objectives of the NMR Shared Resource are: (1) to continue efforts both to maintain state-of- the-art equipment and to enhance the resource to meet DCI members' needs; (2) to continue to monitor advances in NMR approaches aimed at characterizing biomolecular systems and to implement useful new techniques; (3) to prepare and submit internal and external proposals as appropriate to fund new equipment acquisitions and to incorporate advanced technology in order to support user needs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-45
Application #
9620032
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-01-01
Budget End
2019-12-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Feng, Yun; Wang, Yanru; Liu, Hongliang et al. (2018) Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. Mol Carcinog 57:216-224
Naqvi, Ibtehaj; Gunaratne, Ruwan; McDade, Jessica E et al. (2018) Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis. Mol Ther 26:1020-1031
Wen, Juyi; Liu, Hongliang; Wang, Lili et al. (2018) Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy. J Thorac Oncol 13:660-675
Li, Bo; Wang, Yanru; Xu, Yinghui et al. (2018) Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer 142:2303-2312
Gearhart-Serna, Larisa M; Jayasundara, Nishad; Tacam Jr, Moises et al. (2018) Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations. J Environ Public Health 2018:5610462
Bakthavatsalam, Subha; Sleeper, Mark L; Dharani, Azim et al. (2018) Leveraging ?-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. Angew Chem Int Ed Engl 57:12780-12784
Dai, Ziwei; Mentch, Samantha J; Gao, Xia et al. (2018) Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nat Commun 9:1955
Powell Gray, Bethany; Kelly, Linsley; Ahrens, Douglas P et al. (2018) Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A 115:4761-4766
Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
Hudson, Kathryn E; Rizzieri, David; Thomas, Samantha M et al. (2018) Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study. Br J Haematol :

Showing the most recent 10 out of 513 publications