The Cancer Center Isolation Facility (CCIF) is a 30,000 square foot, stand-alone building located in the heart of the Duke biomedical campus and dedicated to cancer research. Its physical plant supports work with hazardous materials at biosafety level 2 or 3, recombinant DNA, chemotherapeutics, as well as the maintenance of immunosuppressed and specific pathogen free rodents. Immunocompromised mice (outbred athymic nude mice and inbred Nod SCID gamma (NSG) mice) are bred within CCIF and are available to all investigators at Duke who have an approved IACUC animal protocol. The CCIF also maintains numerous xenograft lines derived from both pediatric and adult primary and metastatic tumors, including various brain tumors, sarcomas, melanomas, and breast cancers. CCIF personnel advise or suggest mentors to DCI investigators who require assistance with breeding services, veterinary or diagnostic services, animal and experimental protocol development, inoculation or testing of cell lines, preferable location of such inoculations, and a large variety of other information pertinent to performing safe and efficient research in the investigation of cancer biology. The 33 current users of CCIF are all DCI members and the CCIF contributed to 334 DCI publications during the funding period. Users represented eight of the nine CCSG-recognized Research Programs: Neuro-Oncology, Cancer Genetics and Genomics, Developmental Therapeutics, Hematologic Malignancies and Cellular Therapies, Tumor Biology, Women's Cancer, Radiation Oncology and Imaging, and Solid Tumor Therapeutics. CCIF also supports the CCSG-supported Optical Molecular Imaging and Analysis Shared Resource. CCIF contains facilities for the conduct of efficacy and toxicity studies that meet Good Laboratory Practice (GLP) regulations as required by the Food and Drug Administration to obtain Investigational New Drug permits. In the past 5 years, upgrades to equipment in the CCIF have occurred through significant investments by the Duke School of Medicine. The immediate and long-term objectives of the CCIF Shared Resource are to continue to provide high-quality barrier facility services, improve and upgrade services when possible, and to provide key expertise and services, including low-cost, high quality animals, to DCI members studying cancer biology and developing new agents for treating or diagnosing human cancers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-45
Application #
9620037
Study Section
Subcommittee I - Career Development (NCI)
Project Start
Project End
Budget Start
2019-01-01
Budget End
2019-12-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Galaz-Montoya, Monica; Wright, Sara J; Rodriguez, Gustavo J et al. (2017) ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem 292:9967-9974
Lanier, Megan L; Park, Hyeri; Mukherjee, Paramita et al. (2017) Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation. Chemistry 23:7180-7184
Shi, Qiong; Liu, Hongliang; Han, Peng et al. (2017) Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. J Invest Dermatol 137:1749-1756
Woyach, Jennifer A; Ruppert, Amy S; Guinn, Daphne et al. (2017) BTKC481S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia. J Clin Oncol 35:1437-1443
Wang, Yanru; Freedman, Jennifer A; Liu, Hongliang et al. (2017) Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer. Int J Cancer 141:731-743
Fayanju, Oluwadamilola M; Hall, Carolyn S; Bauldry, Jessica Bowman et al. (2017) Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer. Am J Surg 214:666-671
Leu, David; Spasojevic, Ivan; Nguyen, Huy et al. (2017) CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. Redox Biol 12:864-871
Sauer, Scott J; Tarpley, Michael; Shah, Imran et al. (2017) Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis 38:252-260
Pan, Yongchu; Liu, Hongliang; Wang, Yanru et al. (2017) Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep 7:44634
Yin, Jieyun; Liu, Hongliang; Liu, Zhensheng et al. (2017) Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Mol Carcinog 56:1663-1672

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