The Biostatistics Shared Resource provides clinical, translational, and scientific researchers at the Duke Cancer Institute (DCI) access to state-of-the-art expertise in biostatistics methods for study design, analysis, and reporting. The Resource's partnerships have embedded biostatistics teams in disease-specific clusters to provide ongoing development of research, grant applications, and clinical protocols. The Biostatistics Shared Resource is led by a newly recruited Director, Dr. Terry Hyslop. She oversees an expert cadre of 9 faculty and 11 staff who partner with DCI disease groups and Research Programs. While initially focused on translational research and clinical trials, the Resource is extending its embedding activities into other cancer research areas, such as health services research, observational studies, epidemiology, basic sciences, and others to meet the needs of the DCI. These partnerships have strengthened grant funding, high impact publications, and created an enhanced research-training environment at DCI. Dr. Hyslop and the Biostatistics Shared Resource also work closely with the DCI's Bioinformatics Shared Resource and Information Systems Shared Resource to establish appropriate breadth and range of expertise to meet DCI needs. Planning and oversight is provided by DCI administrative leadership and the DCI Shared Resources Oversight Committee. The Shared Resource was utilized in over 300 publications since the last review, with approximately 45-55 cancer-related publications per year, each year. There are roughly 119 active projects for 62 DCI investigators across a wide range of disease-sites and CCSG-recognized Research Programs. The Resource also participates in and co- leads the development and testing of appropriate systems for trial data management and linkages through Medidata Rave, Medidata Balance, RedCap, and other tools. It also provides assistance with clinical trial compliance, reporting, and oversight and provides scientific review of all DCI protocols.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-45
Application #
9620047
Study Section
Subcommittee I - Career Development (NCI)
Project Start
Project End
Budget Start
2019-01-01
Budget End
2019-12-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Galaz-Montoya, Monica; Wright, Sara J; Rodriguez, Gustavo J et al. (2017) ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem 292:9967-9974
Lanier, Megan L; Park, Hyeri; Mukherjee, Paramita et al. (2017) Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation. Chemistry 23:7180-7184
Shi, Qiong; Liu, Hongliang; Han, Peng et al. (2017) Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. J Invest Dermatol 137:1749-1756
Woyach, Jennifer A; Ruppert, Amy S; Guinn, Daphne et al. (2017) BTKC481S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia. J Clin Oncol 35:1437-1443
Wang, Yanru; Freedman, Jennifer A; Liu, Hongliang et al. (2017) Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer. Int J Cancer 141:731-743
Fayanju, Oluwadamilola M; Hall, Carolyn S; Bauldry, Jessica Bowman et al. (2017) Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer. Am J Surg 214:666-671
Leu, David; Spasojevic, Ivan; Nguyen, Huy et al. (2017) CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. Redox Biol 12:864-871
Sauer, Scott J; Tarpley, Michael; Shah, Imran et al. (2017) Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis 38:252-260
Pan, Yongchu; Liu, Hongliang; Wang, Yanru et al. (2017) Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep 7:44634
Yin, Jieyun; Liu, Hongliang; Liu, Zhensheng et al. (2017) Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Mol Carcinog 56:1663-1672

Showing the most recent 10 out of 480 publications