Abstract

The Experimental Pathology Shared Service provides UWCCC investigators with histologic preparations of the highest caliber workmanship using a variety of procedures. Techniques range from classical histologic staining methods to cutting edge molecular histopathologic assays, such as immunohistochemical detection of molecules of interest. The facility additionally offers consultation services, by which UWCCC investigators can obtain the assistance of a.Pathologist in the examination and interpretation of their samples. The Pathologists are also available to discuss experimental design with interested investigators. Serial sections , of both frozen and paraffin-embedded material are routinely carried out, as well as autoradiography of tissue sections and cell cultures with appropriate stains. Drs. Ruth Sullivan and Henry C. Pitot offer consultation to investigators whenever the need arises. The ability of UWCCC investigators to fully characterize animal models of human cancer and to test hypotheses regarding mechanisms of neoplastic development in vivo depends on both the technical and diagnostic services of the Experimental Pathology Facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014520-37
Application #
8067990
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
37
Fiscal Year
2010
Total Cost
$180,704
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Pleiman, Jennifer K; Irving, Amy A; Wang, Zhishi et al. (2018) The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PLoS Genet 14:e1007611
Kletzien, Heidi; Macdonald, Cameron L; Orne, Jason et al. (2018) Comparison Between Patient-Perceived Voice Changes and Quantitative Voice Measures in the First Postoperative Year After Thyroidectomy: A Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg 144:995-1003
Kang, Lei; Jiang, Dawei; Ehlerding, Emily B et al. (2018) Noninvasive Trafficking of Brentuximab Vedotin and PET Imaging of CD30 in Lung Cancer Murine Models. Mol Pharm 15:1627-1634
Bulu, Hakan; Sippo, Dorothy A; Lee, Janie M et al. (2018) Proposing New RadLex Terms by Analyzing Free-Text Mammography Reports. J Digit Imaging 31:596-603
Jewett, Patricia I; Gangnon, Ronald E; Elkin, Elena et al. (2018) Geographic access to mammography facilities and frequency of mammography screening. Ann Epidemiol 28:65-71.e2
Albertini, Mark R (2018) The age of enlightenment in melanoma immunotherapy. J Immunother Cancer 6:80
Shull, James D; Dennison, Kirsten L; Chack, Aaron C et al. (2018) Rat models of 17?-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention. Physiol Genomics 50:215-234
Kang, Lei; Jiang, Dawei; England, Christopher G et al. (2018) ImmunoPET imaging of CD38 in murine lymphoma models using 89Zr-labeled daratumumab. Eur J Nucl Med Mol Imaging 45:1372-1381
Melgar-Asensio, Ignacio; Kandela, Irawati; Aird, Fraser et al. (2018) Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging. Invest Ophthalmol Vis Sci 59:4071-4081
Jang, Samuel; Rosenberg, Stephen A; Hullet, Craig et al. (2018) Value of Elective Radiation Oncology Rotations: How Many Is Too Many? Int J Radiat Oncol Biol Phys 100:558-559

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