The flexibility of CCSG Development funds provides the Director with the ability to support evolving opportunities that support the goals established by the leaders of UWCCC. There are three areas where Development Funds play a critical role: start-up support for new faculty;pilot project research funding and the development of new Shared Resources. The Director commits CCSG development funds for start-up support for faculty candidates who provide the most promising opportunities for significant contributions to the Scientific Programs of UWCCC. During the current grant period, UWCCC contributed $2.5 million towards the recruitment of 28 tenure track faculty. These faculty have been awarded approximately $43.4 million in grant funding for a 17 fold return on investment to date. In concert with the priorities established for future development, candidates will be chosen because of their promising potential to conduct laboratory cancer research leading to translation, or to contribute to applied research resulting from translation. Pilot projects are an important mechanism to support early explorations leading to research that will fulfill the discovery through translation mission of UWCCC. A coordinated process, similar to an NIH study section, ensures that the resources of UWCCC are used effectively. The process has evolved to align the goal of strengthening cancer-focused collaborative projects that include intra- and trans-disciplinary laboratory and clinical research with translational end-points. During the current grant period. UWCCC funded 85 pilots with $4 million which have generated approximately $23 million in grant awards and 66 publications to date. Shared Resources are one of the most important mechanisms that UWCCC uses to encourage investigators to take advantage of opportunities for collaboration and focus their research on cancer. Scientific opportunity is a powerful enticement, but when it is paired with fiscal benefit, the opportunity is magnified. We will allocate resources for new Shared Resources that will have a significant impact on the translational potential of our research efforts and support areas targeted for future development. Future Shared Resource development in the next grant period will focus on informatics and genomics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA014520-39
Application #
8483776
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-04-25
Project End
2018-03-31
Budget Start
2013-04-12
Budget End
2014-03-31
Support Year
39
Fiscal Year
2013
Total Cost
$446,768
Indirect Cost
$66,047
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Shiyanbola, Oyewale O; Sprague, Brian L; Hampton, John M et al. (2016) Emerging trends in surgical and adjuvant radiation therapies among women diagnosed with ductal carcinoma in situ. Cancer 122:2810-8
Valeri, Linda; Chen, Jarvis T; Garcia-Albeniz, Xabier et al. (2016) The Role of Stage at Diagnosis in Colorectal Cancer Black-White Survival Disparities: A Counterfactual Causal Inference Approach. Cancer Epidemiol Biomarkers Prev 25:83-9
Lu, Weifei; Hong, Hao; Cai, Weibo (2016) Radio-nanomaterials for biomedical applications: state of the art. Eur J Nanomed 8:151-170
Moore, Robert W; Fritz, Wayne A; Schneider, Andrew J et al. (2016) 2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice. Toxicol Appl Pharmacol 305:242-9
Lor, Maichou; Xiong, Phia; Park, Linda et al. (2016) Western or Traditional Healers? Understanding Decision Making in the Hmong Population. West J Nurs Res :
Chang, Julie E; Havighurst, Thomas; Kim, KyungMann et al. (2016) Bendamustine + rituximab chemoimmunotherapy and maintenance lenalidomide in relapsed, refractory chronic lymphocytic leukaemia and small lymphocytic lymphoma: A Wisconsin Oncology Network Study. Br J Haematol 173:283-91
Guckenberger, David J; Pezzi, Hannah M; Regier, Mary C et al. (2016) Magnetic System for Automated Manipulation of Paramagnetic Particles. Anal Chem :
Hernandez, Reinier; Sun, Haiyan; England, Christopher G et al. (2016) CD146-targeted immunoPET and NIRF Imaging of Hepatocellular Carcinoma with a Dual-Labeled Monoclonal Antibody. Theranostics 6:1918-33
Damnernsawad, Alisa; Kong, Guangyao; Wen, Zhi et al. (2016) Kras is Required for Adult Hematopoiesis. Stem Cells 34:1859-71
Zhan, Yonghua; Ai, Fanrong; Chen, Feng et al. (2016) Intrinsically Zirconium-89 Labeled Gd2 O2 S:Eu Nanoprobes for In Vivo Positron Emission Tomography and Gamma-Ray-Induced Radioluminescence Imaging. Small 12:2872-6

Showing the most recent 10 out of 1196 publications