; The Experimental Pathology Laboratory (EPL) provides high quality, cost effective histology and histology related services to University of Wisconsin Carbone Cancer Center (UWCCC) members and generates slides for traditional histologic, as well as advanced molecular techniques. The services provided by the EPL significantly enhance the ability of UWCCC investigators to fully characterize animal models of human cancer and to test hypotheses of mechanisms of neoplastic development in vivo. Classical histology procedures remain a mainstay of the EPL's work. In addition, the EPL performs a wide variety of immunohistochemical (IHC) and immunofluorescence (IF) techniques and is capable of developing specialized IHC and IF protocols in response to requests from UWCCC members. The services provided by the EPL are highly utilized. In 2011, the EPL served 39 UWCCC members from seven different Scientific Programs. In this period, the EPL processed and embedded in paraffin more than 7000 tissue specimens, generated more than 50,000 slides from paraffin embedded tissues and produced approximately 5,000 slides from frozen sectioned tissue. In addition, the EPL offers consultation services to UWCCC members for examination and interpretation of specimens, in experimental design and with standard and advanced imaging techniques. Ruth Sullivan, V.M.D., Ph.D. serves as the faculty director ofthe EPL. She is a board-certified veterinary pathologist who also holds a Ph.D. in molecular biology. She has over 20 years of experience in veterinary medicine and biomedical research and has been engaged in research involving rodent models for 15 years. In addition to directing the EPL, Dr. Sullivan provides expert pathology consultation and education services to UWCCC members who utilize animal models and provides histopathology tutorial sessions monthly. The EPL is managed by Jane Calenzo who has 33 years of experience in histology laboratories and has served as manager for 25 years.

Public Health Relevance

The Experimental Pathology Laboratory (EPL) provides technical and professional support for analysis of tissue structure in rodent models of human cancer. The EPL provides pathology support for all major experimental animal models being used at the University of Wisconsin Carbone Cancer Center (UWCCC).

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Wisconsin Madison
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Oberley, Christopher C; Bilger, Andrea; Drinkwater, Norman R (2015) Genetic background determines if Stat5b suppresses or enhances murine hepatocarcinogenesis. Mol Carcinog 54:959-70
Wisinski, Kari B; Ledesma, Wendy M; Kolesar, Jill et al. (2015) A phase I study to determine the maximum tolerated dose and safety of oral LR-103 (1?,24(S)Dihydroxyvitamin D2) in patients with advanced cancer. J Oncol Pharm Pract 21:416-24
Kolesar, Jill M; Pomplun, Marcia; Havighurst, Tom et al. (2015) Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer. J Oncol Pharm Pract 21:128-31
Simoncic, Urban; Perlman, Scott; Liu, Glenn et al. (2015) Comparison of NaF and FDG PET/CT for assessment of treatment response in castration-resistant prostate cancers with osseous metastases. Clin Genitourin Cancer 13:e7-e17
Zhao, Z; Wang, L; Xu, W (2015) IL-13R?2 mediates PNR-induced migration and metastasis in ER?-negative breast cancer. Oncogene 34:1596-607
Chakravarty, Rubel; Hong, Hao; Cai, Weibo (2015) Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature. Curr Drug Targets 16:592-609
Wu, Jianqiang; Salva, Katrin A; Wood, Gary S (2015) c-CBL E3 ubiquitin ligase is overexpressed in cutaneous T-cell lymphoma: its inhibition promotes activation-induced cell death. J Invest Dermatol 135:861-8
LoConte, Noelle K; Razak, Albiruni R A; Ivy, Percy et al. (2015) A multicenter phase 1 study of ? -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors. Invest New Drugs 33:169-76
Romens, Sarah E; McDonald, Jennifer; Svaren, John et al. (2015) Associations between early life stress and gene methylation in children. Child Dev 86:303-9
Ayvaci, Mehmet U S; Alagoz, Oguzhan; Chhatwal, Jagpreet et al. (2014) Predicting invasive breast cancer versus DCIS in different age groups. BMC Cancer 14:584

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