The Cancer Risk and Prevention Program (Program 6) is an extremely interdisciplinary program involving 32 members from 11 Departments representing basic, translational, and clinical investigators. Members have a total of $ 7,327,303 in peer-reviewed funding, including $1,403,749 from the NCI. Over the past grant cycle, Program 6 members generated a total of 269 peer-reviewed publications, including 8% intraprogrammatic, and 25% interprogrammatic publications. The overall objectives of the Cancer Risk and Prevention Program are to understand the genetic, psychological, behavioral, and socio-environmental basis of cancer and to disseminate cancer control efforts through research in our local community. The specific scientific goals are (1) to elucidate the genetic and environmental basis, as well as the mechanisms of progression, for common cancers (breast, ovarian, colorectal, prostate, lung, skin, and blood), and to translate this new knowledge into clinical and public health practice;(2) to develop animal models for chemoprevention studies and develop biomarkers for early detection of cancer;(3) to identify genetic, psychological, and bio-behavioral bases of cancer risk and prevention;and (4) to establish an organized outreach research effort in the Southside Chicago neighborhoods to enhance and empower their participation and utilization of University of Chicago research, educational and clinical services, thereby reducing the disparities in cancer and other health outcomes and their modifiable determinants in the community. The heterogeneity of research within the Program is a strength, but it also presents challenges, given the wide-ranging foci of scientific investigations from basic scientific research in carcinogenesis through preclinical and clinical translational research. Particular strengths of the Program include molecular epidemiology, basic and clinical studies in addiction and high-risk health behaviors, and studies of environmental toxicity and population-based genetics. This program encompasses transdisciplinary interactions and collaborations fostered by program-specific activities, by the close proximity of the investigators at the University of Chicago campus and, particularly, by the large collaborative research grants, such as the Center for Interdisciplinary Health Disparities Research, Breast Cancer SPORE, PO1s, and training grants within the Program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-37
Application #
8375687
Study Section
Special Emphasis Panel (ZCA1-RTRB-N)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
37
Fiscal Year
2012
Total Cost
$32,181
Indirect Cost
$11,250
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Li, Gang; Montgomery, Jeffrey E; Eckert, Mark A et al. (2017) An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Nat Commun 8:1775
Stoddart, Angela; Wang, Jianghong; Hu, Chunmei et al. (2017) Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model. Blood 129:2959-2970
Wing, Claudia; Komatsu, Masaaki; Delaney, Shannon M et al. (2017) Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy. Stem Cell Res 22:79-88
Shah, Palak; Trinh, Elaine; Qiang, Lei et al. (2017) Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules 22:
Qiang, Lei; Sample, Ashley; Shea, Christopher R et al. (2017) Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy 13:2086-2103
Morita, Shuhei; Villalta, S Armando; Feldman, Hannah C et al. (2017) Targeting ABL-IRE1? Signaling Spares ER-Stressed Pancreatic ? Cells to Reverse Autoimmune Diabetes. Cell Metab 25:1207
Davis, Trevor L; Rebay, Ilaria (2017) Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina. Development 144:2640-2651
Kathayat, Rahul S; Elvira, Pablo D; Dickinson, Bryan C (2017) A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling. Nat Chem Biol 13:150-152
Hu, Xue; Li, Li; Yu, Xinyi et al. (2017) CRISPR/Cas9-mediated reversibly immortalized mouse bone marrow stromal stem cells (BMSCs) retain multipotent features of mesenchymal stem cells (MSCs). Oncotarget 8:111847-111865
Hasan, Yasmin; Waller, Joseph; Yao, Katharine et al. (2017) Utilization trend and regimens of hypofractionated whole breast radiation therapy in the United States. Breast Cancer Res Treat 162:317-328

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