The Magnetic Resonance Imaging and Spectroscopy (MRIS) Facility provides support for imaging of cells, materials, tissues, small animals, patients, and volunteers. The Facility serves primarily UCCRC investigators, but also investigators in other areas of research. A variety of in vitro and in vivo measurements are offered including: (a) Pre-clinical and clinical evaluation of the effects of novel therapies based on tumor volume, morphology, perfusion, capillary permeability, cell viability from diffusion-sensitive imaging, and other measurements;(b) High resolution imaging of tissue samples;(c) Pre-clinical and clinical development and testing of new imaging methods for early detection and evaluation of cancer, for example novel approaches to Dynamic Contrast Enhanced MRI (DCEMRI) and spectral/spatial imaging;(d) Imaging of cells and tissues in culture;and (e) Development and testing of image-guided therapies including high intensity focused ultrasound. The Facility has an experienced staff. Together the Co-Directors, Drs. Greg Karczmar and Brian Roman provide expertise in MRI physics and technology, cancer imaging, and applications of MRI to study molecular biology and physiology. The Clinical Co-Director, Dr. Mitchell, is an experienced Radiologist with clinical trials expertise. The experienced staff includes Technical Directors for clinical and pre-clinical imaging, a Facility Manager with over 15 years of MRI experience, a Senior Veterinary Technologist with 25 years of experience, and a talented group of technologists and MRI physicists. Collaborative interdisciplinary and translational research is emphasized. For example, the MRIS Core provides support for the recently funded Breast Cancer SPORE, directed by Dr. Olufunmilayo Olopade. In 2007, the resources available to the Facility will be dramatically upgraded. A new state-of-the-art 9.4 Tesla small bore scanner will be installed in the Lynn S. Florsheim MRIS Laboratory, and this scanner will be used for pre-clinical research. This new scanner will significantly increase the spatial resolution and/or signal-to-noise ratio, and also the range of experiments that can be performed. In addition, a new 1.5 Tesla whole body research scanner will dramatically increase the capacity for clinical research. At the same time, the MRIS staff will be increased to include a Nurse Coordinator, and additional MRI technologists, to accommodate the increased volume of research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-37
Application #
8375711
Study Section
Special Emphasis Panel (ZCA1-RTRB-N)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
37
Fiscal Year
2012
Total Cost
$139,646
Indirect Cost
$48,815
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Li, Gang; Montgomery, Jeffrey E; Eckert, Mark A et al. (2017) An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Nat Commun 8:1775
Stoddart, Angela; Wang, Jianghong; Hu, Chunmei et al. (2017) Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model. Blood 129:2959-2970
Wing, Claudia; Komatsu, Masaaki; Delaney, Shannon M et al. (2017) Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy. Stem Cell Res 22:79-88
Shah, Palak; Trinh, Elaine; Qiang, Lei et al. (2017) Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules 22:
Qiang, Lei; Sample, Ashley; Shea, Christopher R et al. (2017) Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy 13:2086-2103
Morita, Shuhei; Villalta, S Armando; Feldman, Hannah C et al. (2017) Targeting ABL-IRE1? Signaling Spares ER-Stressed Pancreatic ? Cells to Reverse Autoimmune Diabetes. Cell Metab 25:1207
Davis, Trevor L; Rebay, Ilaria (2017) Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina. Development 144:2640-2651
Kathayat, Rahul S; Elvira, Pablo D; Dickinson, Bryan C (2017) A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling. Nat Chem Biol 13:150-152
Hu, Xue; Li, Li; Yu, Xinyi et al. (2017) CRISPR/Cas9-mediated reversibly immortalized mouse bone marrow stromal stem cells (BMSCs) retain multipotent features of mesenchymal stem cells (MSCs). Oncotarget 8:111847-111865
Hasan, Yasmin; Waller, Joseph; Yao, Katharine et al. (2017) Utilization trend and regimens of hypofractionated whole breast radiation therapy in the United States. Breast Cancer Res Treat 162:317-328

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