. Based on the previous CCSG review (2007), the recommendations of our External Advisory Committee, and our strategic planning efforts, the UCCCC has identified the expansion of basic, clinical, and translational imaging research as a high priority. To expand our imaging research and improve the clinical management of cancer, the Advanced Imaging Program (Al) has undergone significant restructuring. Specifically, a high priority has been placed on the integration of imaging and imaging analysis methodology into clinical trials to evaluate new therapies and contrast agents, as well as developing and testing new imaging methods. CCSG funds are requested to support one Staff Investigator, Dr. Aytekin Oto, to spearhead these efforts. The Staff Investigator will work closely with the Imaging Working Group, UCCCC senior leaders, and existing or developing Shared Resources, and the Department of Radiology modality-specific laboratories to facilitate translational and clinical imaging research.

Public Health Relevance

Imaging plays a key role in the UCCCC's effort to offer patients state-of-the-art diagnosis and treatment for cancer. The development of 'personalized medicine', will rely heavily on non-invasive methods to assess individual risk, find early cancers, guide treatment delivery, assess therapeutic response, and evaluate and prevent adverse health outcomes. This Staff Investigator position will lead the efforts to apply imaging to cancer care through the collaborative efforts of imaging scientists and clinicians.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
United States
Zip Code
Feng, Christine H; Gerry, Emily; Chmura, Steven J et al. (2015) An image-guided study of setup reproducibility of postmastectomy breast cancer patients treated with inverse-planned intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys 91:58-64
Ming, Mei; Zhao, Baozhong; Shea, Christopher R et al. (2015) Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge. J Allergy Clin Immunol 135:936-45.e4
Ming, Mei; Zhao, Baozhong; Qiang, Lei et al. (2015) Effect of immunosuppressants tacrolimus and mycophenolate mofetil on the keratinocyte UVB response. Photochem Photobiol 91:242-7
Shah, Palak; He, Yu-Ying (2015) Molecular regulation of UV-induced DNA repair. Photochem Photobiol 91:254-64
Ming, Mei; Han, Weinong; Zhao, Baozhong et al. (2014) SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res 74:5925-33
Ramírez, Jacqueline; Kim, Tae Won; Liu, Wanqing et al. (2014) A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469. Pharmacogenet Genomics 24:129-32
Rudra, Sonali; Al-Hallaq, Hania A; Feng, Christine et al. (2014) Effect of RTOG breast/chest wall guidelines on dose-volume histogram parameters. J Appl Clin Med Phys 15:4547
Weng, Liming; Ziliak, Dana; Lacroix, Bonnie et al. (2014) Integrative "omic" analysis for tamoxifen sensitivity through cell based models. PLoS One 9:e93420
Stumpf, Melanie; Zhou, Xuyu; Chikuma, Shunsuke et al. (2014) Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function. Eur J Immunol 44:1737-46
Geeleher, Paul; Cox, Nancy J; Huang, R Stephanie (2014) Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol 15:R47

Showing the most recent 10 out of 354 publications