The UCLA Translational Pathology Shared Resource (TPSR) provides pathology services critical to the success of modern cancer research. Remnant human tissue procurement and distribution, histology services (animal and human tissues, frozen and formalin-fixed paraffin embedded specimens, laser capture microdissection), state-of-the-art digital pathology services (slide scanning and quantitative image analysis) and pathology consultation services (including aid with tissue selection, study design, IRB applications and interpretation of results) are currently available. During the winter of 2008 we will begin to provide immunohistochemistry and in situ hybridization services. TPSR also provides referrals to appropriate subspecialty pathologists interested in developing collaborative research projects. Through hands-on instruction and consultation, TPSR endeavors to make researchers comfortable and confident in independently performing laser capture microdissection and image analysis;TPSR can also perform these services for a fee. The instrumentation, staff technical skills and pathology expertise available in the TPSR are expensive and beyond the budget of most labs. Following the 2002 review, the JCCC and Department of Pathology appointed new leadership. New Co-Directors, Drs. Sarah Dry (STT) and Jonathan Said (HM), are both actively practicing, Board-certified pathologists with extensively published translational, clinical and basic research. These Co-Directors introduced important new cutting-edge technologies (e.g., digital pathology), identified services that researchers wished to have available in the Shared Resource (e.g., immunohistochemistry) and strengthened existing fundamental shared resource services (tissue procurement and distribution, histology). Usage has increased markedly since the last application (2002): up 271% in overall units of service provided and 169% in researchers served. Tissue distribution and histology service usage have each more than doubled in the past five years. TPSR supported more than 150 published research papers, including high profile journals such as Nature, Nature Medicine and Cancer Research. Over $800,000 in institutional support for new equipment since the last review, as well as 175 sq. ft. of additional space from the Department of Pathology for new digital pathology services, demonstrate the UCLA institutional commitment to this Shared Resource. (Please also see Section 6.2.3 on Shared Resources in the History, Description, Essential Characteristics). 70 Cancer Center members representing 11 Cancer Center Program Areas utilized the services of the Translational Pathology Shared Resource during the reporting period. This is a continuing shared resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016042-38
Application #
8392135
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
38
Fiscal Year
2013
Total Cost
$161,232
Indirect Cost
$66,160
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Law, Ivy Ka Man; Jensen, Dane; Bunnett, Nigel W et al. (2016) Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin. Sci Rep 6:22195
Young, Courtney S; Hicks, Michael R; Ermolova, Natalia V et al. (2016) A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Cell Stem Cell 18:533-40
Palanichamy, Jayanth Kumar; Tran, Tiffany M; Howard, Jonathan M et al. (2016) RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation. J Clin Invest 126:1495-511
Van Dyk, Kathleen; Ganz, Patricia A; Ercoli, Linda et al. (2016) Measuring cognitive complaints in breast cancer survivors: psychometric properties of the patient's assessment of own functioning inventory. Support Care Cancer 24:4939-4949
Bostean, Georgiana; Crespi, Catherine M; Vorapharuek, Patsornkarn et al. (2016) E-cigarette use among students and e-cigarette specialty retailer presence near schools. Health Place 42:129-136
Aguilera-Sandoval, Christian R; Yang, Otto O; Jojic, Nebojsa et al. (2016) Supranormal thymic output up to 2 decades after HIV-1 infection. AIDS 30:701-11
Bauer, Margaret R; Harris, Lauren N; Wiley, Joshua F et al. (2016) Dispositional and Situational Avoidance and Approach as Predictors of Physical Symptom Bother Following Breast Cancer Diagnosis. Ann Behav Med 50:370-84
Horvath, Steve; Gurven, Michael; Levine, Morgan E et al. (2016) An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol 17:171
Ganz, Patricia A; Petersen, Laura; Bower, Julienne E et al. (2016) Impact of Adjuvant Endocrine Therapy on Quality of Life and Symptoms: Observational Data Over 12 Months From the Mind-Body Study. J Clin Oncol 34:816-24
Dooley, Larissa N; Ganz, Patricia A; Cole, Steve W et al. (2016) Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer. J Affect Disord 197:43-50

Showing the most recent 10 out of 568 publications