The Gene Regulation (GR) Program Area was founded in 1999, with the goal of encouraging a strong group of UCLA researchers pursuing fundamental mechanisms of gene regulation to initiate and expand studies relevant to cancer. The Program Area's current goals are to study basic mechanisms of gene regulation in normal somatic cells, stem cells, and cancer cells, to provide sophisticated knowledge of gene regulation concepts and methodology to researchers in other JCCC program areas, and to facilitate the transition of basic gene regulation discoveries into clinical applications. We have encouraged our members to focus on cancer through activities that promote the intra- and inter-programmatic exchange of ideas, by recruiting new investigators, by providing seed funds for cancer-relevant projects, and by developing experimental methods to enable state-of-the-art studies in gene regulation. Fifteen years after the GR Program Area was established, our initial expectations have been met and exceeded. Several researchers who previously focused on fundamental mechanisms of gene regulation are now also actively pursuing studies with direct cancer relevance, including translational research.
One aim i s to leverage our current pre-translational studies into direct clinical applications. Other ongoing efforts are aimed at increasing avenues for interaction with members from other JCCC program areas. The Gene Regulation Program Area is comprised of 25 members, including four

Public Health Relevance

Changes in gene expression caused by the aberrant activation of oncogenes and aberrant inactivation of tumor suppressor genes represent a fundamental property of cancer cells. Cancer cells aberrantly express, or fail to express, genes involved in growth and cell cycle control, as well as genes involved in differentiation and other physiological processes. An improved understanding of the fundamental mechanisms of gene regulation, and of the mechanisms responsible for the growth and survival of cancer cells, is likely to lead to novel therapeutic and diagnostic strategies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016042-39
Application #
8635430
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-12-01
Project End
2018-11-30
Budget Start
2014-03-07
Budget End
2014-11-30
Support Year
39
Fiscal Year
2014
Total Cost
$29,265
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Wu, Sheng; Wong, Weng Kee; Crespi, Catherine M (2017) Maximin optimal designs for cluster randomized trials. Biometrics 73:916-926
Douaisi, Marc; Resop, Rachel S; Nagasawa, Maho et al. (2017) CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus. J Immunol 198:2310-2319
Qi, Hangfei; Chu, Virginia; Wu, Nicholas C et al. (2017) Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein. Proc Natl Acad Sci U S A 114:2018-2023
Lu, Jianqin; Liu, Xiangsheng; Liao, Yu-Pei et al. (2017) Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression. Nat Commun 8:1811
Castaneda, Julie T; Harui, Airi; Roth, Michael D (2017) Regulation of Cell Surface CB2 Receptor during Human B Cell Activation and Differentiation. J Neuroimmune Pharmacol 12:544-554
Casillas, Jacqueline; Goyal, Anju; Bryman, Jason et al. (2017) Development of a text messaging system to improve receipt of survivorship care in adolescent and young adult survivors of childhood cancer. J Cancer Surviv 11:505-516
Su, Yapeng; Wei, Wei; Robert, Lidia et al. (2017) Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance. Proc Natl Acad Sci U S A 114:13679-13684
Demer, Linda L; Tintut, Yin; Nguyen, Kim-Lien et al. (2017) Rigor and Reproducibility in Analysis of Vascular Calcification. Circ Res 120:1240-1242
Kiyohara, M H; Dillard, C; Tsui, J et al. (2017) EMP2 is a novel therapeutic target for endometrial cancer stem cells. Oncogene 36:5793-5807
Dock, Jeffrey; Ramirez, Christina M; Hultin, Lance et al. (2017) Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments. PLoS One 12:e0182498

Showing the most recent 10 out of 721 publications