The Cancer Molecular Imaging (CMI) Program Area is comprised of 29 members, including two """"""""split"""""""" members (shared between two program areas), representing two schools and eight departments at UCLA. The NCI and other peer-reviewed cancer-related support for this Program Area is $5.7M. CMI Program Area members have produced a total number of 411 publications, of which 27% are intra-programmatic, 4 1% are inter-programmatic and 44% were in collaboration with investigators at other institutions. The main goals of the CMI Program Area are to develop new molecular imaging technologies and methodologies to provide new insights into cancer biology, to improve the diagnosis and treatment of cancer, and to translate molecular imaging approaches to the clinic. Four themes support this goal: 1) Instrumentation and analytical tools. Next-generation instrumentation provides high-resolution, sensitive and quantitative noninvasive measurement of molecular biomarkers in vivo at low cost, and facilitates adoption of novel tracers in preclinical and clinical imaging centers. 2) Novel molecular Imaging approaches. CMI members develop novel, translatable PET tracers and reporter gene systems. These probes are employed preclinically to study cancer initiation, progression and metastasis, and to predict and monitor treatment response, laying the groundwork for ciinicai translation. 3) Imaging immune responses. Immune regulation plays a key role in the development and control of cancer, as evidenced by new developments in immunotherapeutics. The CMI Program Area is developing a range of probes for imaging immune responses and monitoring cancer immunotherapy in preclinical models and patients. 4) Translational molecular imaging. CMI investigators are advancing clinical molecular imaging of cancer through first-in-human studies of new radiotracers for deoxycytidine kinase activity (dCK), engineered immunoPET probes for imaging of cell surface markers, novel reporter systems for human use, and finally, new applications of current clinical molecular tracers and modalities (e.g., FDG, FLT, as well as MRI/MRSI to investigate metabolism in gliomas and prostate cancer) to improve patient outcomes.

Public Health Relevance

Cancer molecular imaging allows us to visualize the specific alterations that have occurred in cancerous tissues, in preclinical models, and, importantly, in patients. As more and more targeted therapeutics are brought forward, diagnostic tools, including molecular imaging, are becoming critical to understanding cancer biology in specific individuals, and in selecting and monitoring the most appropriate targeted drugs. The CMI Program Area ensures that the next generation of imaging tools will be available to meet these needs.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Glenn, Beth A; Hamilton, Ann S; Nonzee, Narissa J et al. (2018) Obesity, physical activity, and dietary behaviors in an ethnically-diverse sample of cancer survivors with early onset disease. J Psychosoc Oncol 36:418-436
Tsai, Wen-Ting K; Wu, Anna M (2018) Aligning physics and physiology: Engineering antibodies for radionuclide delivery. J Labelled Comp Radiopharm 61:693-714
Lisova, Ksenia; Sergeev, Maxim; Evans-Axelsson, Susan et al. (2018) Microscale radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: A potential PET tracer for clinical imaging of somatostatin receptors. Nucl Med Biol 61:36-44
Chang, Yu-Ling; Rossetti, Maura; Vlamakis, Hera et al. (2018) A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. Mucosal Immunol :
Kiertscher, Sylvia M; Gangalum, Pallavi R; Ibrahim, Grace et al. (2018) A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers. J Neuroimmune Pharmacol 13:219-229
Jia, Qingmei; Bowen, Richard; Dillon, Barbara Jane et al. (2018) Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep 8:7009
Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Leoh, Lai Sum; Kim, Yoon Kyung; Candelaria, Pierre V et al. (2018) Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. J Immunol 200:3485-3494
Hicks, Michael R; Hiserodt, Julia; Paras, Katrina et al. (2018) ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol 20:46-57
Tsang, Eric J; Wu, Benjamin; Zuk, Patricia (2018) MAPK signaling has stage-dependent osteogenic effects on human adipose-derived stem cells in vitro. Connect Tissue Res 59:129-146

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