The original Signal Transduction (ST) Program Area was established in 1997 to bring together researchers Studying a variety of signaling pathways, including pathways initiated by receptors and membrane-mediated events, heterotrimeric G-protein, small G-protein- and protein kinase-mediated intermediate signaling events, and distal transcription factor activation. The ST Program Area sponsored large symposia to promote discussion and to facilitate interaction among ST researchers. Research during this period led to the identification of molecular targets, which then led to the development of signal transduction inhibitors. Because of the translational potential of signal transduction research for cancer therapy, we wanted to create a platform where basic scientists could discuss their studies on signaling pathways with clinicians carrying out clinical trials of signal transduction inhibitors. To create this platform, the ST Program Area was reconfigured in 2007 as the Signal Transduction and Therapeutics (STT) Program Area. The new/revised STT Program Area includes both basic scientists and clinicians.
Our aim i s to have an easy, transparent transition from basic science to the clinic and from the clinic to basic science. During the current funding period, basic science and clinical activities in the STT Program Area have truly become integrated. Our members share a passion to promote new cancer therapies based on basic signal transduction observations. We promote translational aspects of our Program Area by holding meetings and seminars that gather basic scientists and clinicians, who exchange their experience and knowledge on signaling pathways of common interest. The STT Program Area is comprised of 47 members, including four

Public Health Relevance

): Most targeted cancer therapeutics that have been developed to date inhibit specific signaling pathways required for the growth of cancer cells. The Signal Transduction and Therapeutics Program Area brings together basic, translational, and clinical researchers to optimize and speed the development of novel therapeutics that target signaling pathways.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016042-39
Application #
8635436
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-12-01
Project End
2018-11-30
Budget Start
2014-03-07
Budget End
2014-11-30
Support Year
39
Fiscal Year
2014
Total Cost
$28,196
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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