The UCLA Translational Pathology Core Laboratory Shared Resource (TPCL SR), a College of American Pathologists (CAP) accredited biobank, provides pathology services essential for basic, translational and clinical cancer research. Remnant human tissue procurement and distribution, histology services (animal and human tissues, frozen and formalin-fixed paraffin embedded specimens, laser capture microdissection), immunohistochemistry and in-situ hybridization services, state-of-the-art digital pathology services (slide scanning and quantitative image analysis) and pathology consultation services (including aid with tissue selection, study design, IRB applications and interpretation of results) are currently available. The instrumentation, staff technical skills, quality and pathology expertise available in the TPCL are expansive and beyond the budget of most labs. In August 2012, TPCL became the fourth biorepository in the United States to be accredited by the College of American Pathologists (CAP). The TPCL Director, Drs. Sarah Dry (ZY) and Co-Director, Jonathan Said (ZY) are both Board Certified, practicing pathologists who conduct basic, translational and clinical research. They have led the successful application for CAP accreditation, supervised renovations of new laboratory space, implemented state-of-the-art biorepository software used by TPCL and written grants that funded the purchase of Definiens image analysis software and a Leica LMD 7000 laser capture microdissection scope. TPCL links researchers with appropriate subspecialty pathologists interested in developing collaborative research projects. Through hands-on instruction and consultation, TPCL endeavors to make researchers comfortable and confident in independently performing image analysis and laser capture microdissection;TPCL can also perform these services for a fee. TPCL usage has remained relatively constant since 2008, reflecting the critical need for our services. From 07/01/2011- 06/30/2012, the TPCL Shared Resource had 254 users, 138 of whom were JCCC members, representing eight Cancer Center Program Areas. Of the 138 member users, 105 had peer-reviewed funding and 33 did not have peer-reviewed funding.

Public Health Relevance

Translational research and personalized medicine requires high quality human biosamples. TPCL provides a College of American Pathologist's accredited biobank, plus standard pathology services (histology, immunohistochemistry, pathology consultation) and state-of-the-art pathology resources (automated digital analysis, digital slide scanning, laser capture microdissection) required for successful modern cancer research in a cost effective manner to UCLA researchers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016042-39
Application #
8635440
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-12-01
Project End
2018-11-30
Budget Start
2014-03-07
Budget End
2014-11-30
Support Year
39
Fiscal Year
2014
Total Cost
$146,433
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Glenn, Beth A; Hamilton, Ann S; Nonzee, Narissa J et al. (2018) Obesity, physical activity, and dietary behaviors in an ethnically-diverse sample of cancer survivors with early onset disease. J Psychosoc Oncol 36:418-436
Tsai, Wen-Ting K; Wu, Anna M (2018) Aligning physics and physiology: Engineering antibodies for radionuclide delivery. J Labelled Comp Radiopharm 61:693-714
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Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
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Hicks, Michael R; Hiserodt, Julia; Paras, Katrina et al. (2018) ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol 20:46-57
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