The Genetics Program (GN) is committed to fostering intra- and inter-programmatic and collaborative innovative studies that focus on functional genomics. The overall goal of the GN Program is to identify and characterize genetic and genomic changes that drive and/or predict cancer initiation, progression or therapeutic response, thus developing new therapeutic targets. Historically, much of the focus in this Program has been in basic research and discovery;more recently the goal has been broadened to encourage involvement by Program members in translational and clinical studies. The Program's central themes are 1) Cancer Gene, Signatures and Pathway Discovery;2) Epigenetics and Genomic Instability, and 3) Mouse Models of Cancer. The program is led by Irwin Gelman. PhD, who has strong interests in basic and translational aspects of cancer genetics. The GN Program has longstanding strength in basic cancer genetic discovery and functional genomics research. Dr. Gelman's leadership in translating this to new drug/pathway targets and predictive genetic tests has been facilitated by robust inter- and intra-programmatic collaborations, monthly meetings and twice-yearly retreats that emphasize interaction with clinicians, population scientists and translational researchers. Innovative new projects are promoted by the establishment of cutting-edge genetic screening, sequencing and bioinformatics platforms, and by GN-led projects that emphasize highly collaborative studies that will yield new grants and/or high-impact publications. Program members have published 321 publications since 2008;20% were inter-programmatic and 19% were intra-programmatic;22 publications were in journals with an impact factor >10. Current annual total peer-reviewed funding is $7.9M, of which $3.8M is NCI, and the total extramural research funding is $9.2M. The GN Program has 24 members with expertise in mouse models of cancer, molecular analysis of human cancer, genetics and pathways controlling metastasis, epigenomics, bioinformatics and molecular pathology, all of which are fully integrated into the themes within the Program. The Program members come from seven departments at RPCI.
Leadership has reestablished focus on programmatic collaboration to promote translational genetic and genomic research through interactions between basic scientists and clinical investigators. The GN Program bridges cutting-edge genomics and bioinformatics expertise, carefully developed tissue banks and medical informatics, to drive development of team-science approaches to hypothesis-driven research.
|Clyde, Merlise A; Palmieri Weber, Rachel; Iversen, Edwin S et al. (2016) Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci. Am J Epidemiol 184:579-589|
|Wilton, John; Kurenova, Elena; Pitzonka, Laura et al. (2016) Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs. Eur J Drug Metab Pharmacokinet 41:55-67|
|Zhao, Zhiguo; Wen, Wanqing; Michailidou, Kyriaki et al. (2016) Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes Control 27:679-93|
|Goossens, Maria E; Isa, Fatima; Brinkman, Maree et al. (2016) International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics. Arch Public Health 74:30|
|Pharoah, Paul D P; Song, Honglin; Dicks, Ed et al. (2016) PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations. J Natl Cancer Inst 108:|
|Austin, David C; Strand, Douglas W; Love, Harold L et al. (2016) NF-ÎºB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance. Prostate 76:1004-18|
|Sexton, Sandra; Tulowitzki, Ryan; Jones, Craig A et al. (2016) Involvement of the renin-angiotensin system in the development of nephrogenic systemic fibrosis-like lesions in the RenTag mouse model. Clin Exp Nephrol 20:162-8|
|Shafirstein, Gal; Battoo, Athar; Harris, Kassem et al. (2016) Photodynamic Therapy of Non-Small Cell Lung Cancer. Narrative Review and Future Directions. Ann Am Thorac Soc 13:265-75|
|Klinkebiel, David; Zhang, Wa; Akers, Stacey N et al. (2016) DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer. Mol Cancer Res 14:787-94|
|Bistulfi, Gaia; Affronti, Hayley C; Foster, Barbara A et al. (2016) The essential role of methylthioadenosine phosphorylase in prostate cancer. Oncotarget 7:14380-93|
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