It is now clear that tumor-immune system interactions are far more complex than simple CTL-mediated tumor cell killing, and that effectively harnessing the immune system to control human cancers requires an integrated understanding of immune interactions ranging from clinically significant anti-tumor immunity, to counter-regulatory limitation of this immunity, to immune responses that actually support tumor development and survival. The overall goal of the Tumor Immunology and Immunotherapy (Til) program is to translate the understanding of the immune responses to cancer (both anti-tumor and pro-survival) into innovative approaches for the assessment and treatment of patients with cancer. To accomplish this, TH research is focused around four inter-related themes: Theme 1: Biology of immune cell cancers;Theme 2: Mechanisms of immunological tumor rejection;Theme 3;Microenvironment and host-tumor interactions and Theme 4;Immunotherapy and clinical discovery. The Program is co-led by Kelvin Lee, MD and Kunle Odunsi MD, PhD, who have strong interests in both basic and clinical/population aspects of tumor immunology and immunotherapy. Dr. Lee's leadership efforts focus on the basic and preclinical/translational research in the Program, which dovetails with Dr. Odunsi's leadership focus on the translation and clinical research efforts. The ability to translate research is a particular strength of TH, due in large part to the robust and longstanding inter-programmatic and basic science-clinical interactions. This strength has been enhanced over the last funding cycle by the establishment of the RPCI Center for Immunotherapy (CFI), led by Dr. Odunsi. The CFl houses all the RPCI immunotherapy clinical trials and infrastructure, including new cGMP production and clinical immunomonitoring facilities. These initiatives have occurred in conjunction with relocation (in 2008) of TH membership into 50,000 square feet of new contiguous laboratory space in the new RPCI Center for Pharmacology &Genetics, and the ongoing complete renovation of 36,800 sf in the Cancer Cell Center (supported by C06 RR 020132-01 A l , K. Lee PI) to house TH and CFI members. The Program is comprised of 28 members from 8 RPCI departments (Immunology, Pediatrics, Neurosurgery, Medicine, Molecular and Cellular Biology, Gynecologic Oncology, Cancer Prevention and Control, Surgical Oncology and Pathology), whose total peer-reviewed funding is $10.9M (NCI funding $3.2M) and a total funding of $14.2M. This compares to $6.9M peer reviewed/$9.0M total funding at the last renewal. Since the last renewal, 5 TH members have left the Institute and 3 others have moved to other Programs, while 15 new members (9 recruited from outside the Institute) have joined. Of the 481 publications generated over the last funding cycle, 22% are intra-programmatic and 20% are inter-programmatic, 50 publications are in journals with Impact Factor>10. The Program continues to actively translate its basic science into the clinical arena, with 16 active investigator-initiated trials currently accruing.

Public Health Relevance

It has now become clear that various components ofthe immune system play opposing roles in inhibiting cancer growth as well as supporting its survival. The research ofthe Tumor Immunology and Immunotherapy Program seeks to understand how the immune system responds to cancer, and apply this understanding to new and innovative approaches to diagnose and treat patients with cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016056-37
Application #
8738366
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-06-16
Project End
2019-04-30
Budget Start
2014-06-26
Budget End
2015-04-30
Support Year
37
Fiscal Year
2014
Total Cost
$39,194
Indirect Cost
$15,503
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Wintrob, Zachary A P; Hammel, Jeffrey P; Nimako, George K et al. (2017) Insulin use, hormone receptor status and hematopoietic cytokines? circulation in women with diabetes mellitus and breast cancer. Data Brief 11:382-390
Murphy, Maureen E; Liu, Song; Yao, Song et al. (2017) A functionally significant SNP in TP53 and breast cancer risk in African-American women. NPJ Breast Cancer 3:5
Liu, Song; Kumari, Sangeeta; Hu, Qiang et al. (2017) A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer. Elife 6:
Espinal, Allyson C; Buas, Matthew F; Wang, Dan et al. (2017) FOXA1 hypermethylation: link between parity and ER-negative breast cancer in African American women? Breast Cancer Res Treat 166:559-568
Danaher, Patrick; Warren, Sarah; Dennis, Lucas et al. (2017) Gene expression markers of Tumor Infiltrating Leukocytes. J Immunother Cancer 5:18
Oakley, Emily; Bellnier, David A; Hutson, Alan et al. (2017) Surface markers for guiding cylindrical diffuser fiber insertion in interstitial photodynamic therapy of head and neck cancer. Lasers Surg Med 49:599-608
Gage-Bouchard, Elizabeth A (2017) Social support, flexible resources, and health care navigation. Soc Sci Med 190:111-118
Moore, Kathleen N; Tritchler, David; Kaufman, Kenneth M et al. (2017) Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol 147:396-401
Szender, J Brian; Papanicolau-Sengos, Antonios; Eng, Kevin H et al. (2017) NY-ESO-1 expression predicts an aggressive phenotype of ovarian cancer. Gynecol Oncol 145:420-425
Ho, Christine M; McCarthy, Philip L; Wallace, Paul K et al. (2017) Immune signatures associated with improved progression-free and overall survival for myeloma patients treated with AHSCT. Blood Adv 1:1056-1066

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