Historically, it has been labor intensive for RPCI researchers to obtain accurate clinical data from multiple disparate sources in a HIPAA compliant manner. To improve efficiency, RPCI established the Clinical Data Network (CDN) Shared Resource, an operational network of people, databases and IT tools working together to consistently collect, abstract, retrieve, integrate, process, link to bio-specimens, and deliver clinical data in a cost-effective manner. It is the meaningful integration of people, research infrastructures and processes, and Information Technology (IT) resources that makes CDN a unique, nimble and effective shared resource. In fact, thanks to the CDN, researchers at RPCI today can get reliable clinical data in three to six days rather than the three to six weeks required before: In the two years of its existence, the CDN has been successfully developed into a shared resource, and seamlessly integrated into the RPCI translational research process. It is already being successfully used by an increasing number of CCSG peer reviewed members with high user satisfaction. The CDN is led by Carmelo Gaudioso, MD, MBA, PhD, Director of Biomedical Informatics. The CDN provides specialized data management technologies, services, and expertise to CCSG members conducting non-interventional research. It guides investigators through the protocol development process, including regulatory and data requirements, and facilitates the review and approval by Disease Site Research Groups (DSRGs) for their use of bio-specimens and data. It provides Honest Broker (HB) service for the delivery of de-identified data and the re-identification for the subsequent delivery of foliow-up data in a HIPAA compliant manner. To establish interoperability across the disparate databases and facilitate data integration and sharing, the CDN facilitates the creation and adoption of standard data dictionaries and data standards. The CDN collaborates with other Shared Resources, notably the Pathology Resource Network (PRN) and the Data Bank and BioRepository (DBBR), for the annotation and the selection of bio-specimens based on clinical-pathological characteristics. To improve the value of the services provided to CCSG members. Dr. Gaudioso and his staff work closely with the scientific programs to better understand their research and related data requirements. First priority for use is given to peer-review-funded RPCI CCSG members;second priority to non-peer-review- funded CCSG members;third priority to non-members and academic collaborators;and last priority to external users. During the reporting period, the Clinical Data Network Shared Resource has served 28 members from 6 research programs, with 37% utilization by CCSG members with peer reviewed funding. The CCSG support provides 6% of the overall proposed budget.
The CDN provides cost-effective abstraction, retrieval, integration, processing and delivery of accurate and reliable HIPAA-compliant clinical data, with linkages to bio-specimens. This is critical for translational research, and overcomes historical obstacles to cross-platform information integration.
|Ciamporcero, Eric; Miles, Kiersten Marie; Adelaiye, Remi et al. (2015) Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models. Mol Cancer Ther 14:101-10|
|Ma, Yingyu; Hu, Qiang; Luo, Wei et al. (2015) 1?,25(OH)2D3 differentially regulates miRNA expression in human bladder cancer cells. J Steroid Biochem Mol Biol 148:166-71|
|Shen, Li; Sundstedt, Anette; Ciesielski, Michael et al. (2015) Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models. Cancer Immunol Res 3:136-48|
|Adelaiye, Remi; Ciamporcero, Eric; Miles, Kiersten Marie et al. (2015) Sunitinib dose escalation overcomes transient resistance in clear cell renal cell carcinoma and is associated with epigenetic modifications. Mol Cancer Ther 14:513-22|
|Ambrosone, Christine B; Zirpoli, Gary; Ruszczyk, Melanie et al. (2014) Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study. Cancer Causes Control 25:259-65|
|Uekusa, Shota; Kawashima, Hiroyuki; Sugito, Kiminobu et al. (2014) Nr4a3, a possibile oncogenic factor for neuroblastoma associated with CpGi methylation within the third exon. Int J Oncol 44:1669-77|
|Rohrbach, Daniel J; Muffoletto, Daniel; Huihui, Jonathan et al. (2014) Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging. Acad Radiol 21:263-70|
|Röhm, Marc; Grimm, Melissa J; D'Auria, Anthony C et al. (2014) NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis. Infect Immun 82:1766-77|
|Haller, Andrew C; Tan, Wei; Payne-Ondracek, Rochelle et al. (2014) High SPDEF may identify patients who will have a prolonged response to androgen deprivation therapy. Prostate 74:509-19|
|Ambrosone, Christine B; Young, Allyson C; Sucheston, Lara E et al. (2014) Genome-wide methylation patterns provide insight into differences in breast tumor biology between American women of African and European ancestry. Oncotarget 5:237-48|
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