The Small Animal Imaging Shared Resource (SAISR) is a newly developed state-of-the-art imaging facility located in 5300 sq ft. of the Biomedical Research Tower (BRT), home to a majority of CCC members. The SAISR is led by Drs. Periannan Kuppusamy (Director) and Kimeriy Powell (Technical Director) and includes high-resolution small animal imaging equipment, image post-processing hardware and software, technical support personnel, and direct interface to Ohio Supercomputer (OSC) facilities. Animal housing for serial imaging studies is provided by University Laboratory Animal resources and two 100 sq ft suites are available for surgical procedures and animal preparation. The following micro imaging equipment is available within this shared resource: 1) An AVANCE 500 WB NMR Spectrometer and Imaging system (Bruker BioSpin, Germany), 2) A BioSpec 94/30 imaging system (Bruker BioSpin, Germany, 3) An Inveon? PET/CT Imaging system (Siemens, Eriangen Germany), 4) An Inveon? SPECT/PET/CT Imaging system (Siemens, Eriangen Germany), 5) An X-SPECT? SPECT/CT imaging system (Gamma Medica, Northridge, CA, USA), 6) A Vevo 2100 high frequency ultrasound system (VisualSonics, Toronto Canada), and 7) four Electron Paramagnetic Resonance (EPR) imaging systems. The primary mission of the SAISR is to provide high quality micro-imaging data to OSUCCC members at low-cost in an efficient and timely manner. Highly trained and dedicated personnel provide services to allow OSUCCC investigators to perform an imaging experiment from the design to analysis stages. SAISR staff proactively develop new imaging protocols and have implemented a web-based server system where 3D imaging data can be downloaded and interactively viewed by the investigators at their desktops. The development phase of SAISR available imaging modalities have increased from 3 to 7 and the facility has been relocated and expanded to centrally-located space near the CCC's primary vivarium. During the last 12 months the SAISR has provided service to 21 OSUCCC investigators in 5 of 6 OSUCCC Scientific Programs for 47% of the total usage. Three full-time personnel manage and operate the facility, and a comprehensive a year long seminar series has been instituted to educate cancer investigators about small animal imaging and cancer research. Furthermore, we anticipate expansion of this environment with integrated multi-modality optical and ultrasound imaging systems. Collectively, the SAISR leverages outstanding institutional support to provide cutting edge imaging instrumentation and services to support high quality cancer research.

Public Health Relevance

The Small Animal Shared Resource (SAISR) a state-of-the-art small animal imaging facility that provides OSUCCC investigators high resolution imaging equipment, highly trained personnel and outstanding support for quantitative image analysis. The SAISR provides support for high quality cancer investigations in a timely and cost-effective manner within an outstanding institutional research environment.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Ohio State University
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Salem, Galena; Ruppert, Amy S; Elder, Patrick et al. (2015) Lower dose of antithymocyte globulin does not increase graft-versus-host disease in patients undergoing reduced-intensity conditioning allogeneic hematopoietic stem cell transplant. Leuk Lymphoma 56:1058-65
Niederwieser, C; Kohlschmidt, J; Volinia, S et al. (2015) Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia. Leukemia 29:567-75
Billingsley, Caroline C; Cohn, David E; Mutch, David G et al. (2015) Polymerase ? (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing. Cancer 121:386-94
Krok-Schoen, Jessica L; Kurta, Michelle L; Weier, Rory C et al. (2015) Clinic type and patient characteristics affecting time to resolution after an abnormal cancer-screening exam. Cancer Epidemiol Biomarkers Prev 24:162-8
Biddle, Martha J; Lennie, Terry A; Bricker, Gregory V et al. (2015) Lycopene dietary intervention: a pilot study in patients with heart failure. J Cardiovasc Nurs 30:205-12
Jin, Ming; Roth, Rachel; Rock, Jonathan B et al. (2015) The impact of tumor deposits on colonic adenocarcinoma AJCC TNM staging and outcome. Am J Surg Pathol 39:109-15
Llanos, Adana A; Pennell, Michael L; Young, Gregory S et al. (2015) No association between colorectal cancer worry and screening uptake in Appalachian Ohio. J Public Health (Oxf) 37:322-7
Nguyen, Huyen T; Jia, Guang; Shah, Zarine K et al. (2015) Prediction of chemotherapeutic response in bladder cancer using K-means clustering of dynamic contrast-enhanced (DCE)-MRI pharmacokinetic parameters. J Magn Reson Imaging 41:1374-82
Berman-Booty, Lisa D; Thomas-Ahner, Jennifer M; Bolon, Brad et al. (2015) Extra-prostatic transgene-associated neoplastic lesions in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Toxicol Pathol 43:186-97
Pant, Shubham; Martin, Ludmila K; Geyer, Susan et al. (2014) Baseline serum albumin is a predictive biomarker for patients with advanced pancreatic cancer treated with bevacizumab: a pooled analysis of 7 prospective trials of gemcitabine-based therapy with or without bevacizumab. Cancer 120:1780-6

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