The Tissue and Data Acquisition and Analysis Core (TDAAC) functions as the primary tissue acquisition and processing facility for human solid tissue and hematopoietic specimens to support translational research at the Virginia Commonwealth University Health System (VCUHS). To this end, TDAAC 1) maintains a biorepository, operating under an IRB approved protocol to store samples for future research studies and 2) collects samples for specific investigator-initiated IRB approved research projects and investigator-initiated clinical trials. For each specimen, TDAAC collects and maintains the associated clinical and pathological annotation and can provide this information under an anonymous honest broker system or for specific IRB approved protocols. These services are achieved through leveraging a network of interdepartmental and informatics relationships within VCU. TDAAC acquires specimens along with informed consent from patients undergoing routine clinical procedures at the VCUHS. TDAAC staff, in collaboration with Department of Pathology based Molecular Morphology Genomics Laboratory and Laser Capture Microdissection Laboratory, can provide samples of extracted, quality controlled RNA and DNA from human tissues, frozen sections, and cryopreserved samples of viable hematopoietic neoplasias. The specimen acquisition process ensures that the primary purpose of the specimen for patient care is maintained and the quality of the specimen is optimal for biomedical research. TDAAC's strategic importance resides in the growing need in modern cancer research for investigators to demonstrate that studies in model systems have relevance in human cancers. This shared resource provides services to a wide range of investigators from Virginia Commonwealth University (VCU) Massey Cancer Center (MCC), the VCU research community, and collaborating institutions outside VCU. Over the years 2008-2010, the shared resource collected 2,428 solid tissue and hematopoietic specimens and obtained informed consent on nearly 1,600 patients and provided services to over 30 MCC members. For the period of January 1, 2010 to December 31, 2010, use by MCC members accounted for approximately 74% of services provided.
Access to human tissue in the form of both cancerous and normal cells is critical to furthering our understanding of cancer. The Tissue and Data Acquisition and Analysis Core provides such tissue in combination pathologic annotation to MCC investigators.
|Ding, Boxiao; Parmigiani, Anita; Divakaruni, Ajit S et al. (2016) Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep 6:22538|
|Terracina, Krista P; Graham, Laura J; Payne, Kyle K et al. (2016) DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer. Cancer Immunol Immunother 65:1061-73|
|Alotaibi, Moureq; Sharma, Khushboo; Saleh, Tareq et al. (2016) Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Radiat Res 185:229-45|
|Truchan, Hilary K; Cockburn, Chelsea L; Hebert, Kathryn S et al. (2016) The Pathogen-Occupied Vacuoles of Anaplasma phagocytophilum and Anaplasma marginale Interact with the Endoplasmic Reticulum. Front Cell Infect Microbiol 6:22|
|Menezes, M E; Das, S K; Minn, I et al. (2016) Detecting Tumor Metastases: The Road to Therapy Starts Here. Adv Cancer Res 132:1-44|
|Agarwal, Stuti; Bell, Catherine M; Taylor, Shirley M et al. (2016) p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res 14:66-77|
|Gewirtz, David A (2016) The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy. Cancer Res 76:5610-5614|
|Lafata, Jennifer Elston; Shay, L Aubree; Brown, Richard et al. (2016) Office-Based Tools and Primary Care Visit Communication, Length, and Preventive Service Delivery. Health Serv Res 51:728-45|
|Korwar, Sudha; Morris, Benjamin L; Parikh, Hardik I et al. (2016) Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP). Bioorg Med Chem 24:2707-15|
|Ge, Xiuchun; Shi, Xiaoli; Shi, Limei et al. (2016) Involvement of NADH Oxidase in Biofilm Formation in Streptococcus sanguinis. PLoS One 11:e0151142|
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