Small Animal Imaging Core Facility The goal of the Small Animal Imaging (SAI) core is to provide advanced animal imaging services, including imaging acquisition and image analysis tools that will facilitate cancer research at UNC and beyond. The imaging ability provided by the core allowed sophisticated monitoring of animal models, especially for studies focusing on cancer etiology and molecular therapeutics. The SAI core currently houses 10 imaging devices, including two 3T Siemens MR scanners, a 9.4T Bruker small animal MR scanner, a GE Explore animal PET/CT scanner, a UNC-designed high resolution SPECT scanner, a high resolution microCT for specimens (SCANCO), a high frequency ultrasound system (VisualSonics), and three IVIS optical imaging systems with capability for both bioluminescence and fluorescence imaging. Three additional imaging devices will be added to the SAI core in 2010: a GE SPECT/CT, a Fluorescence Molecular Tomography system, and a novel carbon nanotube-based CT. The SAI core currently supports 54 research projects. The SAI core requests $115,958 in CCSG funds, representing 12% its operating costs;63% of the core's use is allocated to Cancer Center members. The increase in funding is requested to support the additional personnel and service contracts for new imaging equipment. For the next funding cycle, the SAI core proposes two major goals: expanding imaging, education and training services and developing multimodality imaging technology and analysis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-35
Application #
8340291
Study Section
Subcommittee G - Education (NCI)
Project Start
2011-05-23
Project End
2015-11-30
Budget Start
2011-05-23
Budget End
2011-11-30
Support Year
35
Fiscal Year
2011
Total Cost
$224,344
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Quach, Bryan; Furey, Terrence S (2017) DeFCoM: analysis and modeling of transcription factor binding sites using a motif-centric genomic footprinter. Bioinformatics 33:956-963
Wang, Sheng; Wacker, Daniel; Levit, Anat et al. (2017) D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science 358:381-386
Westmoreland, Katherine D; Montgomery, Nathan D; Stanley, Christopher C et al. (2017) Plasma Epstein-Barr virus DNA for pediatric Burkitt lymphoma diagnosis, prognosis and response assessment in Malawi. Int J Cancer 140:2509-2516
Kang, SunAh; Fedoriw, Yuri; Brenneman, Ethan K et al. (2017) BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis. J Immunol 198:2602-2611
Ehe, Ben K; Lamson, David R; Tarpley, Michael et al. (2017) Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1. Biochem Biophys Res Commun 491:767-772
Conway, Kathleen; Edmiston, Sharon N; Parrish, Eloise et al. (2017) Breast tumor DNA methylation patterns associated with smoking in the Carolina Breast Cancer Study. Breast Cancer Res Treat 163:349-361
Williams, Lindsay A; Olshan, Andrew F; Hong, Chi-Chen et al. (2017) Alcohol Intake and Breast Cancer Risk in African American Women from the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 26:787-794
Evon, Donna M; Golin, Carol E; Stewart, Paul et al. (2017) Patient engagement and study design of PROP UP: A multi-site patient-centered prospective observational study of patients undergoing hepatitis C treatment. Contemp Clin Trials 57:58-68
Barnash, Kimberly D; The, Juliana; Norris-Drouin, Jacqueline L et al. (2017) Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. ACS Comb Sci 19:161-172
Hatkevich, Talia; Kohl, Kathryn P; McMahan, Susan et al. (2017) Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction. Curr Biol 27:96-102

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