Tissue Procurement and Biospecimens Core Facility The major objective of the Tissue Procurement and Biospecimens Core Facility is to support and enhance cancer-related translational, clinical, population and basic science research. This is achieved by providing UNC Lineberger Comprehensive Cancer Center members with a centralized, coordinated, quality controlled, quality-assured facility for the procurement, processing, storage, and distribution of biologic specimens. Such specimens include normal and malignant tissue, blood, buccal samples, cell lysates, saliva, urine and adipose, collected from human subjects with and without cancer. The facility procures biologic specimens for utilizing its own IRB-approved protocols. The facility now serves over 50 IRB approved protocols. It will begin to serve the UNC Health Registry Cancer Survivorship Cohort protocol that incorporates a global consent process developed to support the enrollment into the planned 10,000 patient Cancer Survivorship Cohort with well-characterized, clinically annotated biologic specimens. The facility provides laboratory support and storage capabilities for both clinical and epidemiologic cancer research studies. For investigator driven studies, the core accommodates investigator specific needs and applications, including planning and performing experiments to optimize specimen handling. In addition, the facility supports many pilot studies and institutionally supported studies to obtain preliminary data for subsequent peer-reviewed grants, especially for newly recruited clinical faculty. During 2009, the facility collected tissue samples from 1094 patients and distributed 674 samples to LCCC members. A major service of the facility is DNA extraction, quantitation, normalization, quality analysis and aliquoting. Additionally, the core coordinates and integrates activities with several other cores, including the Translational Core, the Genomics Core, the Proteomics Core, the Next Generation Sequencing and Genotyping Core, the Biostatistics and Data Management Core, and the Bioinformatics Core. All aspects of sample processing are tracked, using a unique identifier, from arrival in the lab through processing, storage, and disbursement. Distribution of biologic specimens and corresponding data is facilitated by the Lineberger Data-Biologies Governance/Sharing Committees and guidelines. We request $297,439 in CCSG funds, representing 20% of the core's operating costs for 2010. Over 90% of the tissues use was by LCCC members. Members accounted for 79 % of blood and other biospecimen use.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-39
Application #
8786529
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-12-01
Budget End
2015-11-30
Support Year
39
Fiscal Year
2015
Total Cost
$288,881
Indirect Cost
$73,404
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zhang, Yugen; Dittmer, Dirk P; Mieczkowski, Piotr A et al. (2018) RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner. MBio 9:
Abida, Wassim; Sawyers, Charles L (2018) Targeting DNA Repair in Prostate Cancer. J Clin Oncol 36:1017-1019
Bigi, Rachele; Landis, Justin T; An, Hyowon et al. (2018) Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A 115:E11379-E11387
Liu, Jianfang; Lichtenberg, Tara; Hoadley, Katherine A et al. (2018) An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics. Cell 173:400-416.e11
Song, Lixin; Dunlap, Kaitlyn L; Tan, Xianming et al. (2018) Enhancing Survivorship Care Planning for Patients With Localized Prostate Cancer Using a Couple-Focused mHealth Symptom Self-Management Program: Protocol for a Feasibility Study. JMIR Res Protoc 7:e51
Guseman, Alex J; Perez Goncalves, Gerardo M; Speer, Shannon L et al. (2018) Protein shape modulates crowding effects. Proc Natl Acad Sci U S A 115:10965-10970
Xu, Bowen; Cai, Ling; Butler, Jason M et al. (2018) The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports 10:675-683
Gartlan, Kate H; Bommiasamy, Hemamalini; Paz, Katelyn et al. (2018) A critical role for donor-derived IL-22 in cutaneous chronic GVHD. Am J Transplant 18:810-820
Lee, Andrew L; Sapienza, Paul J (2018) Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase. Front Mol Biosci 5:47
Parada Jr, Humberto; Hall, Marissa G; Boynton, Marcella H et al. (2018) Trajectories of Responses to Pictorial Cigarette Pack Warnings. Nicotine Tob Res 20:876-881

Showing the most recent 10 out of 1525 publications