-Tissue Procurement and Biospecimens Processing (TPFB) Shared Resource The mission of the Tissue Procurement and Biospecimens Processing Shared Resource (TPFB) is to support and enhance cancer-related translational, clinical, population and basic science research. This is achieved by providing UNC Lineberger Comprehensive Cancer Center members with a centralized, coordinated, quality- controlled, quality-assured facility for the procurement, processing, storage, and distribution of biologic specimens. The facility procures biologic specimens for biobanking purposes utilizing its own IRB-approved protocols. In addition, the facility now serves over 75 investigator-initiated IRB approved protocols, with both blood and tissue being collected Additional services include consultation on biospecimen collection issues, execution of pilot studies, assay development, and help with grant and publication submissions. The facility is staffed with experienced personnel with over 30 years of combined tissue procurement, biospecimen processing, nucleic acid extraction, and biorepository lab experience. The TPFB shared resource has a long- term relationship with the Department of Surgical Pathology, such that most requests for research tissues are routed through the core to insure that each project has undergone the appropriate IRB review. This has resulted in a smooth and seamless centralized collection process for the banking of solid tissues, both fresh and frozen, and blood products. All aspects of sample processing are tracked from the time the technician is paged to retrieve the sample to arrival in the lab, through all processing steps, storage location, and ending with distribution. In the last funding period, the tumor procurement and biospecimen processing efforts of the facility resulted in over 60 high impact cancer-related publications. The total operating budget of the facility is $1,001,303 of which we are requesting $299,303 from the CCSG. The previous budget $891,328 for which CCSG support was 22% resulted in >200,000 specimens collected from 3600 unique cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-43
Application #
9614911
Study Section
Subcommittee I - Career Development (NCI)
Project Start
Project End
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
43
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Lim, Joseph K; Liapakis, Ann Marie; Shiffman, Mitchell L et al. (2018) Safety and Effectiveness of Ledipasvir and Sofosbuvir, With or Without Ribavirin, in Treatment-Experienced Patients With Genotype 1 Hepatitis C Virus Infection and Cirrhosis. Clin Gastroenterol Hepatol 16:1811-1819.e4
Wang, Gary P; Terrault, Norah; Reeves, Jacqueline D et al. (2018) Prevalence and impact of baseline resistance-associated substitutions on the efficacy of ledipasvir/sofosbuvir or simeprevir/sofosbuvir against GT1 HCV infection. Sci Rep 8:3199
Phillips, Bonnie; Van Rompay, Koen K A; Rodriguez-Nieves, Jennifer et al. (2018) Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques. J Virol 92:
Lianga, Noel; Doré, Carole; Kennedy, Erin K et al. (2018) Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset. PLoS Genet 14:e1007029
Allott, Emma H; Geradts, Joseph; Cohen, Stephanie M et al. (2018) Frequency of breast cancer subtypes among African American women in the AMBER consortium. Breast Cancer Res 20:12
Dhungel, Bal Mukunda; Montgomery, Nathan D; Painschab, Matthew S et al. (2018) 'Discovering' primary effusion lymphoma in Malawi. AIDS 32:2264-2266
Cameron, Jennifer E; Rositch, Anne F; Vielot, Nadja A et al. (2018) Epstein-Barr Virus, High-Risk Human Papillomavirus and Abnormal Cervical Cytology in a Prospective Cohort of African Female Sex Workers. Sex Transm Dis 45:666-672
Stanley, Christopher C; van der Gronde, Toon; Westmoreland, Kate D et al. (2018) Risk factors and reasons for treatment abandonment among children with lymphoma in Malawi. Support Care Cancer 26:967-973
Dronamraju, Raghuvar; Jha, Deepak Kumar; Eser, Umut et al. (2018) Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity. Nucleic Acids Res 46:1331-1344
Koehler, Jennifer W; Miller, Andrew D; Miller, C Ryan et al. (2018) A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma. J Neuropathol Exp Neurol 77:1039-1054

Showing the most recent 10 out of 1525 publications