The objective of the Exposure Facility is to provide a highly specialized shared resource to support the scientific needs of NYUCI members for animal exposure research in carcinogenesis models and administration, as well as analytical chemistry to measure exposure in both animal and human samples. In the last competing renewal, the Experimental Animal and Exposure Facility consisted of two integrated units, the Animal Care and Exposure Unit and the Inhalation Exposure Unit, which provide specialized animal care, technical assistance for experiments with rodent species involving delivery of carcinogenic and toxic chemicals for challenge experiments, or chemoprevention/chemotherapy via various routes of exposure including inhalation, systemic, dermal, and oral administration. These unique services for animal exposure are not offered elsewhere at NYUSOM. In recent years, the influences of metals, often associated with inhaled air pollution particulate matter or nanoparticles, are being investigated In ongoing studies in animal and human exposures. To effectively meet the evolving research needs of NYUCI Investigators for metal analyses which frequently involve specialized rodent inhalation exposures to carcinogenic metals, ambient air pollution or contrived particulate atmospheres, many of which are comprised of metal nanoparticles, the Analytical Chemistry Shared Resource, a previously stand-alone shared resource since 1975, Is now incorporated as the Analytical Chemistry Unit within the Experimental Animal and Exposure Facility. The Analytical Chemistry Unit will continue to provide NYUGl investigators with routine access to Atomic Absorption (AA) and X-Ray Fluorescence (XRF) spectroscopy for the qualitative and quantitative determination of metal content in biological and environmental samples. This newly merged shared resource entitled the

Public Health Relevance

In recent years, the influences of metals, often associated with inhaled air pollution particulate matter, or with manufactured or environmental nanoparticles, have been shown to cause human diseases and cancer. The Exposure Facility provides support for measuring metals in human exposure and animal models of exposure to metals and other cancer-causing agents via inhalation and different routes of administration and testing of therapeutic agents for the prevention and treatment of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016087-33
Application #
8436443
Study Section
Subcommittee G - Education (NCI)
Project Start
2013-03-01
Project End
2018-02-28
Budget Start
2013-04-01
Budget End
2014-02-28
Support Year
33
Fiscal Year
2013
Total Cost
$78,906
Indirect Cost
$32,354
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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