The objective of the Exposure Facility is to provide a highly specialized shared resource to support the scientific needs of NYUCI members for animal exposure research in carcinogenesis models and administration, as well as analytical chemistry to measure exposure in both animal and human samples. In the last competing renewal, the Experimental Animal and Exposure Facility consisted of two integrated units, the Animal Care and Exposure Unit and the Inhalation Exposure Unit, which provide specialized animal care, technical assistance for experiments with rodent species involving delivery of carcinogenic and toxic chemicals for challenge experiments, or chemoprevention/chemotherapy via various routes of exposure including inhalation, systemic, dermal, and oral administration. These unique services for animal exposure are not offered elsewhere at NYUSOM. In recent years, the influences of metals, often associated with inhaled air pollution particulate matter or nanoparticles, are being investigated In ongoing studies in animal and human exposures. To effectively meet the evolving research needs of NYUCI Investigators for metal analyses which frequently involve specialized rodent inhalation exposures to carcinogenic metals, ambient air pollution or contrived particulate atmospheres, many of which are comprised of metal nanoparticles, the Analytical Chemistry Shared Resource, a previously stand-alone shared resource since 1975, Is now incorporated as the Analytical Chemistry Unit within the Experimental Animal and Exposure Facility. The Analytical Chemistry Unit will continue to provide NYUGl investigators with routine access to Atomic Absorption (AA) and X-Ray Fluorescence (XRF) spectroscopy for the qualitative and quantitative determination of metal content in biological and environmental samples. This newly merged shared resource entitled the "Exposure Facility" now consists of three integrated units, namely, the Animal Care and Exposure Unit, the Inhalation Exposure Unit and the Analytical Chemistry Unit. This reorganization allows consolidation of manpower and significantly increases the flexibility and cost-effectiveness of this shared resource to provide seamless integration of exposure research with metal analysis and provide expertise in experimental design and conduct for cancer-related studies from exposure to necropsy services and metal measurements in animal and human exposures.

Public Health Relevance

In recent years, the influences of metals, often associated with inhaled air pollution particulate matter, or with manufactured or environmental nanoparticles, have been shown to cause human diseases and cancer. The Exposure Facility provides support for measuring metals in human exposure and animal models of exposure to metals and other cancer-causing agents via inhalation and different routes of administration and testing of therapeutic agents for the prevention and treatment of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016087-34
Application #
8765176
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
34
Fiscal Year
2014
Total Cost
$70,163
Indirect Cost
$28,769
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Jin, Honglei; Yu, Yonghui; Hu, Young et al. (2015) Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines. Oncotarget 6:522-36
Zhou, Sherry; Weitzman, Michael; Vilcassim, Ruzmyn et al. (2015) Air quality in New York City hookah bars. Tob Control 24:e193-8
Brocato, Jason; Costa, Max (2015) 10th NTES Conference: Nickel and arsenic compounds alter the epigenome of peripheral blood mononuclear cells. J Trace Elem Med Biol 31:209-13
Cohen, Mitchell D; Vaughan, Joshua M; Garrett, Brittany et al. (2015) Acute high-level exposure to WTC particles alters expression of genes associated with oxidative stress and immune function in the lung. J Immunotoxicol 12:140-53
Ota, Mitsuhiko; Horiguchi, Masahito; Fang, Victoria et al. (2014) Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-? in gastric tissue. Cancer Res 74:2642-51
McKinney, Caleb; Zavadil, Jiri; Bianco, Christopher et al. (2014) Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication. Cell Rep 6:9-17
Vazquez-Cintron, Edwin J; Vakulenko, Maksim; Band, Philip A et al. (2014) Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm. PLoS One 9:e85517
Jhaveri, Komal; Chandarlapaty, Sarat; Lake, Diana et al. (2014) A phase II open-label study of ganetespib, a novel heat shock protein 90 inhibitor for patients with metastatic breast cancer. Clin Breast Cancer 14:154-60
Wu, Meng; Yang, Feikun; Ren, Zhihua et al. (2014) Identification of the nuclear localization signal of SALL4B, a stem cell transcription factor. Cell Cycle 13:1456-62
Kaneko, Syuzo; Bonasio, Roberto; SaldaƱa-Meyer, Ricardo et al. (2014) Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin. Mol Cell 53:290-300

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